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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis: Symposium held in Rome/Italy, April 3–6, 1979 de A. Waring

Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis: Symposium held in Rome/Italy, April 3–6, 1979: Archives of Toxicology, cartea 3

A. Waring Editat de J. Clemmesen, D. M. Conning, D. Henschler, F. Oesch
en Limba Engleză Paperback – iun 1980

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Specificații

ISBN-13: 9783540095842
ISBN-10: 3540095845
Pagini: 348
Ilustrații: VIII, 338 p. 5 illus.
Dimensiuni: 170 x 244 x 18 mm
Greutate: 0.55 kg
Ediția:Softcover reprint of the original 1st ed. 1980
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Archives of Toxicology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Dose Response Relationship in Long-Term Exposure to Low Levels of Carcinogens in Animals.- Epidemiological Studies of Occupational Carcinogens.- Incidence of Hepato-Carcinoma in Relation to Aflatoxin Intake.- Epidemiological Studies of Medically Used Drugs.- Estimation of the Risks of Ionising Radiation.- Discussion.- Dose Response Relationship of Carcinogenic Effects on Target Organs or Tissues.- Formation and Subsequent Repair of Alkylation Lesions in Tissues of Rodents Treated with Nitrosamines.- Dose-Response Relationship in the Primary Lesion of Strong Electrophilic Carcinogens.- Non Linear Pharmacokinetic Parameters Need to be Considered in High Dose/Low Dose Extrapolation.- Glutathione Thresholds in Reactive Metabolite Toxicity.- Dose Dependence of Early Cellular Changes During Liver Carcinogenesis.- Binding Kinetics of Vinyl Chloride and Vinyl Bromide at Very Low Doses.- Discussion.- Dose Response Relationship of Biochemical Mechanisms Affecting Species Differences in Response.- Enzymes Controlling Tissues Levels of Reactive Metabolites Including Irreversible Inactivations.- Activating Enzymes: Multiple Monooxygenase Forms with Different Substrate Preferences as Related to Toxic Effects.- Glucuronic Acid Conjugation in the Metabolism of Chemical Carcinogens by Rodent Cells.- Species Differences in Activating and Inactivating Enzymes Related to in Vitro Mutagenicity Mediated by Tissue Preparations from these Species.- The Ah Locus. A Gene with Possible Importance in Cancer Predictability.- Dose-Response Relationship of Rat Aryl Hydrocarbon Hydroxylase and Epoxide Hydratase Induction.- Repair.- Different Basic Mechanisms in DNA Repair.- Possible Determinants for the Differential Susceptibility of Mammalian Cells and Tissues to Chemical Carcinogens.- Reaction of Benzo(a)pyrene and 7,12-Dimethylbenz(a)anthracene with DNA of Various Rat Tissues in Vivo.- Discussion.- Risk Assessment.- Epidemiological and Animal Data as a Basis for Risk Assessment.- An Approach to the Assessment of the Risk to Man from DNA Damaging Agents.- Range of Experimental Evidence in Assessing Potential Human Carcinogenicity.- Procedures for Assessing Risk at Low Levels of Exposure.- Limited Usefulness of Mathematical Models for Assessing the Carcinogenic Risk of Minute Doses.- Discussion.- Summaries of the Chairmen.- Author Index.