Toxicological Aspects of Food Safety: Proceedings of the European Society of Toxicology Meeting held in Copenhagen, June 19–22, 1977: Archives of Toxicology, cartea 1

Young Scientists Award Lecture 1977: An Investigation into the Value of Some Clinical Biochemical Tests in the Detection of Minimal Changes in Liver Morphology and Function in the Rat.- Toxicological Aspects of Food Safety. Introduction to the Symposium.- Nutritional Evaluation of Low-Erucic-Acid Rapeseed Oils.- Food Additives.- Pesticides and Heavy Metals as Food Contaminants.- Toxicokinetics.- Toxicological Aspects of Food Safety — Carcinogenicity and Mutagenicity.- Significance of Induction Phenomena.- Evaluation of Food Safety. National and International Aspects.- Drug Biotransformation and Hepatotoxicity. Studies with Bromobenzene in Isolated Hepatocytes.- Hepatotoxicity of Bile Acids with Special Reference to Cheno-Treatment (Abstract).- Metabolic Activation of Methyldopa and Other Catechols.- Clinical Aspects of Drug-Induced Hepatitis.- Hepatotoxicity in Patients with Liver Disease.- Halothane Hepatitis.- Hypersensitivity Reactions to Food Colours with Special Reference to the Natural Colour Annatto Extract (Butter Colour).- The Use of Radionuclides for the Quantitative Evaluation of Drug Local Irritancy (Abstract).- Stimulation of DNA Synthesis in Mouse and Rat Lung Following Administration of Butylated Hydroxytoluene.- Effects of Rapidly Phosphorylated Substrates Fructose, Sorbitol, Xylitol (Glycerol): Toxic or Metabolic.- Study and Evaluation of Organic Lead Levels in Fishes and Phytoplankton Near Otranto (Abstract).- Drug-Induced Changes in Serum Alkaline Phosphatase and Alanine Aminotransferase Activities not Related to Hepatic Injuries.- Evaluation of Organ Weight Differences in Toxicological Experiments.- Comparative Cardiovascular Toxicity of Trazodone and Imipramine in the Rat.- Liver Injury and Multiple Drug Therapy.- Hepatotoxicity of Citalopram inRats and First-Pass Metabolism.- Toxicologic Findings of 3-Aryl-triene-steroidal-16,17-acetonamide (ATSA) (Abstract).- Biochemical Effects of Chronically Administered Suspending Agents on Mitochondrial Metabolism and Hepatic Mixed Function Oxidases in Rat, Mice and Hamster.- Effect of Ethylenethiourea on Hepatic Microsomal Enzymes in the Rat.- Comparative Study of the Protective Effect of an Anabolic Steroid. The 19-Nortestosterone-Phenylpropionate (19NTPP), on Liver Steatosis Induced by Amanita phalloides and White Phosphorus in Rats.- Experimental Study of Bonaphthon in the Maternal-Embryonic Complex (Abstract).- Chimpanzees Sulfate Lithocholate Similar to Man (Abstract).- Influence of Some Thiol Compounds on the CCl4 Hepatotoxicity (Abstract).- Thromboelastography Behaviour in Rats Submitted to Experimental Liver Intoxication (Abstract).- Routine Clinical Electroretinography in Dogs (Abstract).- A New Procedure for Estimation of Nitrovin and Carbadox Residues and Their Metabolites in Food of Animal Origin.- Glutathione Turnover in Isolated Hepatocytes (Abstract).- Covalent Binding of 2,4-Diaminoanisole and 2,4-Diaminotoluene in vivo.- Comparative Research of Certain Methods in Evaluation of Hepatotoxicity of Chemical Agents (Abstract).- Hepatotoxic Effect of Thioacetamide (TAM) on NADP-Linked Enzymes, Aminotransferases and Glutamate Dehydrogenase.- A Histological Review of the Rat Liver Poisoned by Carbontetrachloride and Treated by Piracetam (Abstract).- The Effect of Piracetam in Rats Poisoned by Carbontetrachloride.- Hepato- and Thyreotoxicity of Tifemoxone.- Toxicological Studies on a New Veterinary Antibiotic Turimycin.- Metabolism of 2,4,5,2?,5?-Pentachlorobiphenyl by Lung and Liver Microsomes.- Hepatic Clearance and Disposition of Hydroxyethylrutosides.-Changes in the Hepatic Copper Content after Treatment with Foreign Compounds.- Absorption and Excretion of 1-Amino-2-Naphthol-6-Sulphonic Acid in Rats and Rabbits.- Drug Excretion into Eggs. An Autoradiographic Study.- The Metabolism of 3H-Benzo(a)pyrene by Hepatic Microsomes from Rats Treated with Tetrachlorodibenzo-p-dioxin (Abstract).- Induction of Drug Metabolizing Enzymes in Different Rat Tissues by TCDD.- Lysosomal Enzymes in Hepatic Injury Induced by Bromobenzene.- Increase of Hepatic and Serum Aldehyde Dehydrogenase Activity after TCDD Treatment.- A Simple and Sensitive Assay of 7-Ethoxycoumarin in Deethylation (Abstract).- Induction of Arylhydrocarbon Hydroxylase and UDP Glucuronosyl Transferase by PCB in Hepatic Cell Cultures.- Enhancement of Cytosolic Carboxylesterase by Phenobarbital in the Rat.- A New Method for Hepatocyte Function Exploration (T.M.B. Test) Applied to the Rat in Experimental Toxicology (Abstract).- Modifying Effects of Styrene on the Catalytic Properties of Some Microsomal Enzymes.- Specific Modification of the Properties of the N-Hydroxylase. Relationship with Carcinogenesis by Aromatic Amides.- A Very Sensitive Gas Chromatographic Method for the Evaluation of Styrene Oxidase and Styrene Oxide Hydratase Activities.- A Gas Chromatographic Method for the Evaluation of the Vinyl Epoxidase Activity.- The Fate of Curcumin in the Rat (Abstract).- The Use of Food Additives in Sweden.- Hemiglobin Formation in vitro Induced by Azo Dyes and Their Metabolites.- Peroral Toxicity of Orange RN in Pigs. Early Haematological Changes.- Peroral Toxicity of Orange RN in Pigs. Ultrastructure of Hepatic Lesions (Abstract).- Toxicology of Triethyllead, Methylmercury and Cadmium, Determined in Chick Embryo Brain Cell Cultures.- Reversible Inhibition of Spermatogenesis with an Indenopyridine (20–438).- Relative Teratogenicity of Selected Anhydrides (Abstract).- Effects of Rapeseed Oil Compared to Hydrogenated Marine Oil in Rats. Histopathological Effects of Erucic Acid and Isomers on the Heart.- Changes in Liver Tyrosine Aminotransferase after Acute and Chronic Administration of Morphine in the Rat.- Retarded Elimination of a High-Molecular Enzyme-Substrate-Complex after Hydroxyethyl-Starch-Infusion.- Drug Metabolism in Man: In vivo and in vitro Correlations.- Pharmacokinetics of Dextropropoxyphene in Acute Poisoning.- Suitability of Different Breeds of Rabbits for Experimental Atherosclerosis (Abstract).- Results of Comparative Toxicity Tests on Mini-Pigs, Beagles and Wistar-Rats with d-Norgestrel (Abstract).- Metabolism of L(+)- and D(-)-Tartaric Acids in Different Animal Species.- Influence of Diet and Strain of Rat on Kidney Damage Observed in Toxicity Studies.- Influence of Drugs on Bile Acid Excretion.- Pharmacological Properties of the Optical Isomers of Ketamine. (Abstract).- The Influence of Arrhythmogenic Substances on the E.C.G. of Rats Calcified by High Doses of Vitamin D2.- Extrapolation of Carcinogenicity Data to Low Doses with a Dose-Response Study of the Binding of Benzo(a)pyrene to Rat Liver DNA.- A Closed Inhalation System for Pharmacokinetic and Metabolism Studies of Volatile Compounds with Small Laboratory Animals.- Effects of Diazepam on DFP Intoxicated Mice in the Absence and Presence of Obidoxime (Abstract).- Pharmacological and Toxicological Investigations on the New Bulgarian Drug Lonetil (Abstract).- Metabolism of Benzo(a)pyrene Catalyzed by Human Lung Microsomes (Abstract).- Stimulation of the Synthesis, in vivo, of Zoxazolamine Hydroxylase in Young Female Rat by Bixa orellana L. Extract(Abstract).- Structural and Biochemical Changes in Rat Hepatic and Extrahepatic Tissues Following a Single Oral Dose of TCDD (Abstract).- Author Index.