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Radioionidation Reactions for Pharmaceuticals: Compendium for Effective Synthesis Strategies

Autor H.H. Coenen, John Mertens, Bernard Mazière
en Limba Engleză Paperback – 18 noi 2010
Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them.
The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radio-iodination reactions.
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Specificații

ISBN-13: 9789048171491
ISBN-10: 9048171490
Pagini: 116
Ilustrații: XI, 101 p.
Dimensiuni: 160 x 240 x 6 mm
Greutate: 0.17 kg
Ediția:Softcover reprint of hardcover 1st ed. 2006
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Professional/practitioner

Cuprins

Iodine Radionuclides.- Iodinated Radiopharmaceuticals.- Methods of Radioiodination.- Iodinated Radiopharmaceuticals.- Expert System.- Guidelines for Radioiodination.

Recenzii

From the reviews:
"This short book is a compendium of information on the preparation of radioiodine pharmaceuticals. It is … a collection of mature, well-tested ideas about the preparation of radioiodine pharmaceuticals. … this succinct volume may be of interest to the specialist in radiopharmaceutical preparation." (Walter Loveland, JACS, Vol. 128 (48), 2006)

Caracteristici

Describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them, based on state-of-the-art research The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties