Cantitate/Preț
Produs

Randomised Response-Adaptive Designs in Clinical Trials

Autor Anthony C. Atkinson, Atanu Biswas
en Limba Engleză Paperback – 4 noi 2019
Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.




After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 47940 lei  6-8 săpt.
  CRC Press – 4 noi 2019 47940 lei  6-8 săpt.
Hardback (1) 55460 lei  6-8 săpt.
  CRC Press – 26 dec 2013 55460 lei  6-8 săpt.

Preț: 47940 lei

Preț vechi: 56400 lei
-15% Nou

Puncte Express: 719

Preț estimativ în valută:
9176 9538$ 7601£

Carte tipărită la comandă

Livrare economică 04-18 februarie 25

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9780367378974
ISBN-10: 0367378973
Pagini: 340
Dimensiuni: 156 x 234 x 20 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția Chapman and Hall/CRC

Public țintă

Professional Practice & Development

Cuprins

Introduction: Stories and Data. Adaptive Design: Controversies and Progress. Randomised Balanced Sequential Treatment Allocation. Response-Adaptive Designs for Binary Responses. Response-Adaptive Designs for Continuous Responses. Response-Adaptive Designs for Longitudinal Responses. Optimum Biased-Coin Designs with Covariates. Optimum Response-Adaptive Designs with Covariates. Optimal Response-Adaptive Designs with Constraints. Adaptive Design: Further Important Issues. Appendix. Bibliography. Index.

Notă biografică

Anthony C. Atkinson is an Emeritus Professor of Statistics at the London School of Economics and Political Science.


Atanu Biswas is a professor in the Applied Statistics Unit at the Indian Statistical Institute, Kolkata.

Descriere

This book presents methods for the randomized allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. The authors compare various designs of clinical trials, include real examples of clinical trials, and present simulations of many procedures for small to moderate-sized samples. They also use results from the optimum design of experiments to create powerful and flexible adaptive designs.