Cantitate/Preț
Produs
Total produse
Vezi coșul
Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease de S.H. Fatemi

Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease

Editat de S.H. Fatemi
en Limba Engleză Hardback – 22 iun 2008
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 120587 lei  6-8 săpt.
  Springer – 4 noi 2014 120587 lei  6-8 săpt.
Hardback (1) 106004 lei  39-44 zile
  Springer – 22 iun 2008 106004 lei  39-44 zile

Preț: 106004 lei

Preț vechi: 139479 lei
-24% Nou

Puncte Express: 1590
Preț estimativ în valută:
20296€ • 21135$ • 16840£

Carte tipărită la comandă

Livrare economică 10-15 februarie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9780387767604
ISBN-10: 0387767606
Pagini: 443
Ilustrații: XXIII, 443 p.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 0.82 kg
Ediția:2008
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Descriere

Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.
This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

Cuprins

The Reelin Gene and Its Functions in Brain DevelopmentCheng-Chiu Huang, MSGabriella D’Arcangelo, PhD*Apolipoprotein E Receptor 2 and Very Low Density Lipoprotein Receptor: An OverviewDr. Hans H. Bock*Prof. Dr. Joachim HerzChemistry of ReelinYves Jossin, PhD*The C-terminal region of Reelin: structure and functionMitsuharu Hattori, PhD*Crystal Structure of Reelin RepeatsJunichi Takagi, PhD*Comparative Anatomy and Evolutionary Roles of ReelinGundela Meyer, MD, PhD*Reelin / Dab1 Signaling in the Developing Cerebral CortexEric C. Olson, PhD*Christopher A. Walsh, MD, PhDUltrastructural Localization of Reelin Rosalinda C. Roberts, PhD*Emma Perez-Costas, PhDReelin and Cyclin-Dependent Kinase 5Toshio Ohshima, MD, PhD*Reelin and the CerebellumRobert F. Hevner, MD, PhD*Reelin and Radial Glial CellsEckart Forster, PhDShanting Zhao, MDMichael Frotscher, MD*Reelin and CognitionShenfeng Qiu, PhDEdwin John Weeber, PhD*Protein Kinases and Signaling Pathways that are Activated by ReelinJonathan A. Cooper, PhD*Nathaniel S. Allen, BSLibing Feng, PhDThe Relationship of Oxytocin and Reelin in the BrainGeorge D. Pappas, PhD*C. Sue Carter, PhDReelin and Thyroid HormoneManuel Alvarez-Dolado, PhD*A Tale of Two Genes: Reelin and BDNFThomas Ringstedt, PhD*Reelin, Liver, and LymphaticsBrigitteSamama, PhD*Nelly Boehm, MD, PhDReelin and Cajal-Retzius CellsJean-Marc Mienville, PhD*Reelin and OdontogenesisFrancoise Bleicher*Henry MagloireMarie-Lise CoubleJean-Christophe MaurinHomozygous and Heterozygous Reeler Mouse MutantsPatricia Tueting, PhD*Graziano Pinna, PhDErminio Costa, MDReelin and LissencephalyElena Parrini, PhDRenzo Guerrini, MD*The Role of Reelin in Etiology and Treatment of Psychiatric DisordersS. Hossein Fatemi, MD, PhD*Teri J. Reutiman, BATimothy D. Folsom, MSReelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in SchizophreniaErminio Costa, MD*Ying Chen, PhDErbo Dong PhDDennis R. Grayson, PhDAlessandro Guidotti, MDMarin Veldic, MDEpigenetic Modulation of Reelin Function in Schizophrenia and Bipolar DisorderHamid Mostafavi Abdolmaleky, MD*Cassandra L. Smith PhDJin-Rong Zhou, PhDSam Thiagalingam, PhDReelin Gene Polymorphisms in Autistic DisorderCarla Lintas PhDAntonio Maria Persico, MD*Alzheimer’s and ReelinArancha Botella-Lopez, BSJavier Saez-Valero, PhD*Reelin and StrokeKunlin Jin, MD, PhD*Reelin and Pancreatic Cancer Kimberly Walter, BS Michael Goggins, MD*

Recenzii

From the reviews:
"The glycoprotein reelin, involved in a multitude of important neurobiological processes including embryogenesis and brain development, is the focus of this informative and interesting book. … The intended audience includes researchers in the field and clinicians. Clinicians who are interested in understanding the importance of epigenetic factors involved in neuropsychiatric disorders would be find this book helpful. … This is an excellent summary of the current state of research findings on this putatively important glycoprotein." (Michael J. Schrift, Doody’s Review Service, July, 2009)
“The whole book is dedicated just to one biopolymer, reelin, which is a major secretory glycoprotein with biological activity in various processes of our body. … The book consists of 28 chapters presented by international group of experts. … book will be very useful as foundation for analysis of this emerging novel glycoprotein for biochemists, molecular biologists, neuroscientists, and clinicians specialized in psychiatric disorders.” (G. Ya. Wiederschain, Biochemistry, Vol. 75 (5), 2010)

Textul de pe ultima copertă

Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.

Caracteristici

Provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies