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Regenerative Nephrology

Editat de Michael S. Goligorsky
en Limba Engleză Hardback – 15 iun 2021
Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.


  • A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes
  • A new section on tissue engineering of the kidney of interest to nephrologists and urologists
  • An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies
  • A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues
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Specificații

ISBN-13: 9780128233184
ISBN-10: 0128233184
Pagini: 528
Ilustrații: 125 illustrations (50 in full color)
Dimensiuni: 216 x 276 mm
Ediția:2
Editura: ELSEVIER SCIENCE

Cuprins

Section 1: Kidney Development and Regeneration
1. Nephrogenesis in Health and Disease
Adrian S. Woolf and Sophie L. Ashley
2. Renal organogenesis in the lymph node microenvironment
Maria Giovanna Francipane
3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology
Oren Pleniceanu Benjamin Dekel
4. Nephrogenesis in malnutrition
Brian B. Ratliff, May M. Rabadi, and Selin Celikoyar
Section 2: Modulators of Regeneration
5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease
Ross Doyle and Catherine Godson
6. T-cell in kidney injury and regeneration
Li Li, Dylan Baer, and Mark D. Okusa
7. Monocytes and dendritic cells in injury and regeneration
Elise N. Erman, Meryl C. Nath, Matthew D. Cheung, Anupam Agarwal, and James F. George
8. Mast cells in kidney regeneration
Eric Douglas, Nicholas Charles, and Ulrich Blank
Section 3: Stem Cells in Regenerative Processes
9.Regeneration and replacement of endothelial cells and renal vascular repair
David P. Basile and Mervin C. Yoder
10. Stem cells in regenerative processes: Induced pluripotent stem cells
Kenji Osafune
11. Nephroprotective effect of urine-derived stem cells for renal injury
Yuanyuan Zhange and Anthony Atala
12. Amniotic stem cells and their exosomes
Jing Ji and Li Yang
13. Regenerative potential of stem-cell-derived extracellular vesicles
Hoon Young Choi and Hyeong Cheon Park
14. Stem cell therapies in diabetes
Sevim Kahraman, Danielle Diegisser, and Ercument Dirice
Section 4: Causes of Regenerative Failure
15. Progression of kidney disease as a maladaptive response to injury
Xuezhu Li, Fend Ding, Kyung Lee, and John Cijiang He
16. Molecular mechanisms of cellular senescence
Jamil Nehme, Marta Varela-Eirin, and Marco Demaria
17. Characteristics of senescent cells
Roland Schmitt and Anette Melk
18. Stress-induced senescence of tubular cells
David P. Baird, David A. Ferenbach, and Joseph V. Bonventre
19. Stress-induced senescence as a forme fruste of chronic kidney disease- A case for failed regeneration
Michael S. Goligorsky
20. Premature vascular aging and senescence in chronic kidney disease
Thomas Ebert and Peter Stenvinkel
21. Injury and regeneration in renal aging
Janka Babickova, Hai-Chun Yang, and Agnes B. Fogo
22. Gender-dependent mechanisms of injury and repair
Joel Neugarten and Ladan Golestaneh
Section 5: Kidney Engineering
23. Glomerular stem cells
Laura Lasagni, Benedetta Mazzinghi, and Paola Romagnani
24. Reconstitution of the kidney glomerular capillary wall
Titilola D. Kalejaiye, Jordan A. Holmes, Rohan Bhattacharya, and Samira Musah
25. Microfluidic modeling of glomerulus and tubular appartus
Gretchen J. Mahler and Stephanie Zhang
26. Matrix scaffolds in kidney engineering
Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando
Section 6: Emerging Clinical Aspects of Regenerative Therapy
27. Reprogramming toward kidney regeneration: New technologies and future promises
Yun Xia and Juan Carlos Izpisua Belmonte
28. Therapy cell reconditioning
Michael S. Goligorsky
29. Senomorphic, senolytic, and rejuvenation therapies
Xiang Yang Zhu and Lilach O. Lerman
30. Natural products in regeneration Rachel B. Wilson, Jason J. Lee, Geoffrey Pickering, and Nica M. Borradaile 
31. Nanotargeting to the kidney
Ryan M. Williams, Chintan Kapadia, Edgar A. Jaimes, and Daniel A. Heller
32. Small molecules in regeneration
Amanda E. Crunk, Aneta Przepiorski, and Neil Hukriede
33. Systems biology in diagnosis and reamtnet of kidney disease
Jennifer Schaub and Matthias Kretzler
34. Overview of ethical concerns raised by kidney organoids
Paola Nicolas and Ira Bedzow
35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies
Joshua Hunsberger and Sita Somara

Recenzii

"The authors of Regenerative Nephrology have empowered a group of the leading investigators to provide a comprehensive overview of regenerative processes in the kidney. It spans the subject from cellular physiology to models and the first clinical trials of stem cell therapy. This book fills a gap in this rapidly expanding field. It will be an invaluable reference to the specialist investigator and a useful overview for those in nephrology or regenerative medicine who wish to become fully up to date with this important subject." --Christopher S. Wilcox, MD, PhD, George E. Schreiner Chair of Nephrology,Director, Center for Hypertension, Kidney and Vascular Health, Chief, Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA
"Dr. Goligorsky has assembled an outstanding group of authors for his "Regenerative Nephrology" book. The publication of this authoritative work is timely. State-of-the-art knowledge about the phylogeny, ontogeny, and mediators of tissue regeneration is discussed and is critical in pursuing the potential role of stem cells in regenerative processes. The kidney is the organ responsible for total body homeostasis, therefore focusing on regeneration in acute and chronic kidney disease is very appropriate. Moreover, Goligorsky is an internationally prominent researcher in understanding the pathophysiology of kidney disease. Regenerative Nephrology has important sections dealing with the clinical aspects of stem cell therapy including potential risks and ethical issues. I highly recommend this important book, not just for scientists studying the kidney, but for all biomedical scientists, as the dawn of stem cell therapy in humans is emerging for many organs." --Robert W. Schrier, MD, Professor of Medicine, University of Colorado, School of Medicine, Denver, CO, USA
"With this book, Dr Goligorsky, along with his impressive collection of highly prominent authors, has certainly succeeded in achieving the goal of bringing an up-to-date review of the basic research of regenerative nephrology and its promising clinical applications to the attention of the interested reader. This is a truly international book; although the majority of the outstanding faculty is North American, excellent contributions have been written by Japanese, Australian and European authors…. This book is not only of interest to the basic expert investigator. Also, the interested teacher or clinician who wants to catch a glimpse of what will become possible in the near future in the treatment of a whole range of acute and chronic kidney diseases with these fascinating new tools will find this book a must…. Dr Goligorsky and his contributors have done a great service to most of us ‘non-experts’ by summarizing, in a brilliant manner, the recent advances in this field." --NDT Plus