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Regio- And Stereoselective Catalytic Addition of Amides to Alkynes: From Structure to Function

Autor Mathieu Blanchot
en Limba Engleză Paperback – 31 oct 2009
The enamide moiety is an important substructure often encountered in biologically active compounds and synthetic drugs. Furthermore, enamides and their derivatives are versatile synthetic intermediates for polymerization, [4+2] cycloaddition, crosscoupling, Heck-olefinination, Halogenation, enantioselective addition or asymmetric hydrogenation. Traditional syntheses of this important substrate class involve rather harsh reaction conditions such as high temperatures and/or the use of strong bases. Based on previous work on the addition of secondary amides to alkynes, a new broadly applicable protocol for the catalytic addition of N-nucleophiles such as primary amides, imides and thioamides to terminal alkynes was developed. The choice of ligands and additives determines the regiochemical outcome so that with two complementary catalyst systems, both the E-anti-Markovnikov products and the Z-anti-Markovnikov products can be synthesized highly regio- and stereoselectively.
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Specificații

ISBN-13: 9783838111124
ISBN-10: 3838111125
Pagini: 228
Dimensiuni: 152 x 229 x 12 mm
Greutate: 0.31 kg
Editura: Sudwestdeutscher Verlag Fur Hochschulschrifte