Regulation of Gene Expression by Hormones de Kenneth McKerns

Regulation of Gene Expression by Hormones: Biochemical Endocrinology

Kenneth McKerns

en Limba Engleză Paperback – 15 iul 2012

The International Foundation for Biochemical Endocrinology is incorporated as a nonprofit research and educational organization. It is dedicated to the dissemination of knowledge, cooperative research programs, and cultural interaction on an international basis. The Foundation is concerned with both basic research and practical applications of biological knowledge to the betterment of humanity. Among our interests are global resource management, human reproduction, hormonal regulation of normal and cancer cells, study of aging and degenerative diseases, brain peptides, peptide neurotransmitter compounds, mechanism of action of hormones, peptide hormone synthesis, and recombinant DNA techniques. This monograph is the ninth sponsored by the Foundation in the Biochemical Endocrinology series. The previous four have been: Hormonally Active Brain Peptides: Structure and Function (1982), K. W. McKerns and V. Pantie, eds.; Reproductive Processes and Contraception (1981), K. W. McKerns, ed.; Synthesis and Release of Adenohypophyseal Hormones (1980), M. Jutisz and K. W. McKerns, eds.; and Structure and Function of the Gonadotropins (1978), K. W. McKerns, ed. These have all been published by Plenum Press.

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Cuprins

1 Hormone Action in Human Breast Cancer: Estrogen Regulation of Specific Proteins.- 1. Introduction.- 2. Are Breast Tumors True Targets for Estrogen Action?.- 3. Estrogen-Regulated Protein Synthesis in Human Breast Cancer.- 4. Conclusions.- References.- 2 Modulation of an Estrogen-Induced Protein in the MCF7 Human Mammary Cancer Cell.- 1. Introduction.- 2. Estrogen-Induced Proteins Released by MCF7 Cells in Culture.- 3. Dissociated Effect of Nonsteroidal Antiestrogens.- 4. Altered Activation of ER by Antiestrogens.- 5. BrdU Incorporation into DNA Inhibits Estrogen-Induced Responses.- References.- 3 The Estrogen-Induced/Dependent Renal Adenocarcinoma of the Syrian Hamster.- 1. Introduction.- 2. Hypophysectomized Hamsters.- 3. Pituitary Cells in Culture.- 4. Renal Adenocarcinoma Cells in Culture.- 5. Hormone Levels in Hamster Serum.- 6. Tumorogenesis via Immunoendocrine Perturbations.- References.- 4 Stimulation of Milk-Fat Synthesis in Mammary Epithelioid Cells by Progesterone.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- References.- 5 Prolactin and Casein Gene Expression in the Mammary Cell.- 1. Introduction.- 2. The Expression of Casein Genes during Pregnancy and Lactation.- 3. Relation between Casein Synthesis and Casein mRNA Concentration.- 4. The Control of Mammary Cell Hypertrophy.- 5. The Hormonal Control of Casein mRNA Translation.- 6. Variations of Casein Gene Transcription and Casein mRNA Stability.- 7. Relation between Prolactin Receptor Occupancy and the Hormonal Response.- 8. Action of Antiprolactin Receptor Antibodies.- 9. Role of Tubulin-Containing Structures in the Transmission of the Prolactin Message to Casein Genes.- 10. Identification of a Possible Second Messenger for Prolactin.- 11. Conclusions.- References.- 6 Sequential Regulation of Gene Expression by Estrogen in the Developing Rat Uterus.- 1. Introduction.- 2. Sequential Development of Estrogen Responsiveness.- 3. Estrogen-Responsive Creatine Kinase.- 4. Regulation of Glucose-6-Phosphate Dehydrogenase.- 5. Considerations for Future Study.- References.- 7 Estrogen-Induced Uterine Hypertrophy.- 1. Introduction.- 2. Estradiol-17?-Stimulated Uterine Hypertrophy.- 3. Estrogen-Stimulated hnRNA Synthesis and Its Maturation to mRNA.- 4. Studies on the mRNA Population of the Rat Uterus.- 5. Estrogen-Stimulated rRNA and tRNA Synthesis.- 6. The Nature of the Proteins on Which Stimulated Ribosome Production Might Depend.- 7. Investigation of the Mode of Action of the Antiestrogen, Tamoxifen.- References.- 8 Regulation of the Expression of the Uteroglobin Gene by Ovarian Hormones.- 1. Introduction.- 2. Structure and Function of Uteroglobin.- 3. Distribution of Uteroglobin and Differential Hormonal Control.- 4. Hormonal Regulation of Uteroglobin Synthesis: Studies with Isolated Uteri, Endometrial Explants, and Endometrial Cell Cultures.- 5. Characterization of Uteroglobin mRNA and Cell-Free Translation Experiments.- 6. Titration of Uteroglobin mRNA by Molecular Hybridization.- 7. Involvement of the Progesterone Receptor.- 8. Hormonal Regulation of Transcription of the Uteroglobin Gene.- 9. Cloning and Characterization of Uteroglobin cDNA.- 10. Quantitation, Isolation, and Structural Analysis of the Uteroglobin Gene.- 11. Concluding Remarks.- References.- 9 Evolution and Regulation of Genes for Growth Hormone and Prolactin.- 1. Evolution.- 2. Regulation.- References.- 10 Androgenic Control of Gene Expression in Rat Ventral Prostate.- 1. Introduction.- 2. Cloning of Rat Ventral Prostate cDNAs.- 3. Expression of RNA in Ventral Prostate.- 4.Isolation of Prostatic-Binding Protein Genomic Clones.- 5. Characterization of Prostatic-Binding Protein Genes.- 6. Future Prospects.- References.- 11 Effects of Ovarian Steroid Hormones on the Brain and Hypophysis: Receptor Modulation and Chromatin Binding.- 1. Hormonal Modulation of Estrogen and Progesterone Receptors in the Rat Brain.- 2. Chromatin Binding in the Brain and Hypophysis.- 3. Summary and Conclusion.- References.- 12 A Cellular Polyprotein from Bovine Hypothalamus: Structural Elucidation of the Precursor to the Nonapeptide Hormone Arginine Vasopressin.- 1. Introduction.- 2. Structural Organization of the AVP—NP II Precursor.- 3. Primary Structure of the AVP—NP II Common Precursor.- 4. Glycine as Signal for Amidation of Oligopeptides.- 5. The 18K Precursor.- 6. Concluding Remarks.- References.