Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept
Autor Panos Macheras, Athanasios A. Tsekourasen Limba Engleză Hardback – 2 ian 2023
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Specificații
ISBN-13: 9783031200243
ISBN-10: 3031200241
Pagini: 129
Ilustrații: XV, 129 p. 1 illus.
Dimensiuni: 155 x 235 mm
Greutate: 0.39 kg
Ediția:1st ed. 2023
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3031200241
Pagini: 129
Ilustrații: XV, 129 p. 1 illus.
Dimensiuni: 155 x 235 mm
Greutate: 0.39 kg
Ediția:1st ed. 2023
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
Cuprins
Part I: Oral Pharmacokinetics.- Chapter 1. From Bateman (1908) To Dost (1953).- Chapter 2. The Unphysical Hypothesis Of Infinite Absorption Time.- Chapter 3. The Finite Absorption Time (Fat) Concept.- Chapter 4. The Rise Of Physiologically Based Finite Time Pharmacokinetic (Pbftpk) Models.- Part II: Bioavailability-Bioequivalence.- Chapter 5. History Of The Bioavailability-Bioequivalence Concepts.- Chapter 6. Therapeutic Equivalence Based On Bioequivalence Studies.- Chapter 7. Bioavailability Under The Prism Of Finite Absorption Time.- Chapter 8. Bioequivalence Under The Prism Of Finite Absorption Time.
Notă biografică
Panos Macheras is Professor emeritus in Biopharmaceutics Pharmacokinetics at the National and Kapodistrian University of Athens (NKUA) in Greece. He has received a BPharm from NKUA and a PhD (Pharmaceutical Chemistry) from NKUA and a PhD (Biopharmaceuitcs Pharmacokinetics) from Chelsea College (now King’s College), University of London. His field of research covers Biopharmaceutics and Pharmacokinetics including classical modelling as well as fractal kinetics approaches. He has published over 180 research articles and 7 books, has supervised 15 PhD students, sits on the editorial board of several scientific journals and has received numerous awards for his scientific contributions. He has served as visiting associate professor at the University of Michigan, Ann Arbor, and is currently adjunct professor at the State University of New York, Buffalo. He also heads the PharmaInformatics Unit of the ATHENA Research Center in Athens, Greece.
Athanasios A.Tsekouras is associate professor in Physical Chemistry at the NKUA. He has received a BSc in Chemistry at NKUA and a PhD at Stanford University. He benefited from a four-year long postdoctoral research appointment at M.I.T. and a one-year appointment as an adjunct professor at the University of Washington, Pullman, working at Pacific Northwest National Laboratory, Richland, Wash. Since then, he has taught Thermodynamics and Spectroscopy at the Department of Chemistry in NKUA, while pursuing mostly research in Surface Science with vapor-deposited molecules that form electrically polarized films. Thus, he had the opportunity to introduce dozens of students in the tricks and pleasures of working with vacuum systems and doing original and unique research. All along, starting from his early undergraduate days, he has maintained a keen interest in model fitting in a variety of problems.
Textul de pe ultima copertă
This book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
This excellent text serves as a historical review of drug absorption kinetics and its application to bioavailability and bioequivalence. However, its main thrust is the application of the authors' innovative new approaches to modifying these processes utilizing concepts of finite absorption time (FAT) and physiologically based finite time pharmacokinetic (PBFTPK) models. The work described in detail is based on the innovative experimental studies, many in depth examples and simulations, and the authors' outstanding theoretical contributions to our understanding of drug gastrointestinal absorption, and drug pharmacokinetics. I found the book to be an enjoyable and enlightening read.
This excellent text serves as a historical review of drug absorption kinetics and its application to bioavailability and bioequivalence. However, its main thrust is the application of the authors' innovative new approaches to modifying these processes utilizing concepts of finite absorption time (FAT) and physiologically based finite time pharmacokinetic (PBFTPK) models. The work described in detail is based on the innovative experimental studies, many in depth examples and simulations, and the authors' outstanding theoretical contributions to our understanding of drug gastrointestinal absorption, and drug pharmacokinetics. I found the book to be an enjoyable and enlightening read.
Professor Leslie Benet, Department of Bioengineering & Therapeutic Sciences, Schools of Pharmacy & Medicine, University of California, San Francisco, USA.
Caracteristici
Novel pharmacokinetic concepts based on recently published work Integration of theory and practice of application of pharmacokinetic models Contains access to software that assists in performing model parameter fits to pharmacokinetic data