This book would like to present the latest findings on different aspects of tumor matrix formation in connection with the tumor progression and metastasis and on alterations in the cellular components of tumor stroma during tumor demarcation and invasion. The contributors shed new light on the relationship between tumor cells and their extracellular microenvironment as well as on the mechanisms of fibrin/fibronectin network formation characteristics in tumors. These reviews provide insights into the formation and organization of tumor matrix during growth and metastasis and also offerthe possibility of learning to interfere with the metastatic cascade by manipulation of adhesion, coagulation and/or fibrinolytic events.