This document is a supplemental safety evaluation report (SSER) for the license renewal application for Vermont Yankee Nuclear Power Station (VYNPS) as filed by Entergy Nuclear Operations, Inc. and Entergy Nuclear Vermont Yankee, LLC. (Entergy or the applicant). By letter dated January 25, 2006, Entergy submitted its application to the United States Nuclear Regulatory Commission (NRC) for renewal of the VYNPS operating license for an additional 20 years. The NRC staff published a safety evaluation report (SER) in two volumes, dated May 2008, which summarizes the results of its safety review of the renewal application for compliance with the requirements of Title 10, Part 54, of the Code of Federal Regulations, (10 CFR Part 54), "Requirements for Renewal of Operating Licenses for Nuclear Power Plants." The NRC staff published Supplement 1 to the SER in October 2009 which documented the safety review results of confirmatory environmentally adjusted fatigue cumulative usage factors analyses for the reactor core spray nozzle and the reactor pressure vessel recirculation outlet nozzle at VYNPS. The applicant provided these analyses in response to the staff's proposed license condition that would require Entergy to perform these fatigue analyses no later than 2 years prior to entering the period of extended operation.