This version of the Safety Risk Management Guidance for System Acquisitions (SRMGSA) cancels SRMGSA Version 2.0. It applies to acquisitions that have a potential effect on safety risk in the National Airspace System (NAS) when the acquired systems are operationally fielded. The SRMGSA includes information pertaining to the Federal Aviation Administration (FAA) Acquisition Management System (AMS) changes, Next Generation Air Transportation System (NextGen) Portfolio Management, and Integrated Safety Management. The body of the document contains only high-level policy and guidance concerning Safety Risk Management (SRM) in acquisitions. The SRMGSA defines the scope, purpose, objectives, and required activities of the FAA's systems safety effort as it applies to SRM for all system acquisitions that provide Communication, Navigation, and Surveillance (CNS), Air Traffic Management (ATM), and other services in the NAS.The SRMGSA applies to all personnel in the ATO performing safety risk assessments on system acquisitions and is of interest to those performing a similar role for the Assistant Administrator of the Office of NextGen (ANG), the Office of Airports (ARP), or other FAA Lines of Business (LOBs). The SRMGSA embodies and contributes to the spirit of the FAA's safety culture. A positive safety culture places a pervasive emphasis on safety and promotes: an inherently questioning attitude, a resistance to complacency, a commitment to excellence, the involvement and accountability of management, and the fostering of personal accountability and corporate self-regulation in safety matters.