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Sex, Gender, and Epigenetics: From Molecule to Bedside de Marianne Legato J

Sex, Gender, and Epigenetics: From Molecule to Bedside

Editat de Marianne Legato J, Dov Feldberg, Marek Glezerman
en Limba Engleză Paperback – 24 mai 2023
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors’ environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.


  • Examines the impact of biological sex and gender on gene expression through epigenetic mechanisms, and its relationship to human biology and disease
  • Presents the current state of our understanding of how environmental experience is translated to future generations in a sex specific manner
  • Features chapter contributions from international leaders in the field
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Specificații

ISBN-13: 9780128239377
ISBN-10: 0128239379
Pagini: 314
Ilustrații: 70 illustrations (30 in full color)
Dimensiuni: 191 x 235 mm
Greutate: 0.61 kg
Editura: ELSEVIER SCIENCE

Public țintă

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, reproductive biology, gender medicine, pediatrics, and bioinformatics; life science researchers; biotechnologists; developmental biologists; genetic counselors

Cuprins

1. Exploring how we become what we are
2. A critical view of the revolution of precision medicine. Genetics, epigenetics, sex, and gender
3. Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells
4. Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits
5. Epigenetics and mental and physical health of children born after ART
6. Epigenetic aspects of male infertility treatment
7. Evidence for assisted reproductive technology associated epigenetic variation in humans
8. Deconvoluting the functional role of DNA methylation in trauma; Implications for epigenetic therapy and prospects of targeted “epigenetic therapy”
9. Antenatal Origins of Health and Disease—A clinician’s perspective
10. Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood
11. DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes
12. Epigenetics and psychiatry
13. Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder
14. Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)–induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe)
15. Genetics and epigenetics of the onecarbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome
16. Novel mechanisms for gene regulation: Chemical tags on RNA molecules
17. Genes, environments, and epigenetics
18. Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring
19. Epigenetic aspects of human reproduction and early pregnancy
20. Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond
21. Mitochondria as epigenetic regulators of reproductive aging
22. The fetal programming of telomere biology hypothesis
23. Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits

Recenzii

“This specialized book is intended for a limited number of researchers who are experts in epigenetic phenomena and want to deepen their understanding of the biological basis of epigenetic effects…. Each chapter is highly detailed and data rich and could stand alone as a research paper. …[F]illed with new data and analysis examining how epigenetic modifications emerge, how epigenetic changes to DNA lead to phenotypes, and how historical experience can affect gene expression. [A] worthy book and valuable contribution for researchers who are deeply interested in the subject matter.” --©Doody’s Review Service, 2023, Mark F. Sanders, PhD (UC Davis College of Biological Sciences)