Cantitate/Preț
Produs
Total produse
Vezi coșul
Sphingolipid Biology de Y. Hirabayashi

Sphingolipid Biology

Editat de Y. Hirabayashi, Y. Igarashi, A.H. Jr. Merrill
en Limba Engleză Hardback – 18 iul 2006
Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (1) 118265 lei  6-8 săpt.
  Springer – dec 2014 118265 lei  6-8 săpt.
Hardback (1) 119007 lei  6-8 săpt.
  Springer – 18 iul 2006 119007 lei  6-8 săpt.

Preț: 119007 lei

Preț vechi: 145131 lei
-18% Nou

Puncte Express: 1785
Preț estimativ în valută:
22776€ • 24028$ • 18981£

Carte tipărită la comandă

Livrare economică 02-16 ianuarie 25

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9784431341987
ISBN-10: 4431341986
Pagini: 531
Ilustrații: XXV, 531 p.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 1 kg
Ediția:2006
Editura: Springer
Colecția Springer
Locul publicării:Tokyo, Japan

Public țintă

Research

Descriere

Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.

Cuprins

Part 1: Overview.- Sphingolipids Synthesis, Transport and Cellular Signaling Serine Palmitoyltransferase.- Part 2: Biosynthesis, Transport of Sphingolipids.- Serine Palmitoyltransferase.- Ceramide Synthase.- Dihydroceramide: Sphinganine D 4-Desaturase and C4-Hydroxylase.- Metabolizing Enzymes Such As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content.- Glucosylceramide and Galactosylceramide Synthase.- Synthesis, Metabolism, and Trans-Bilayer Movement of Long-Chain Base.- Molecular Mechanism of Ceramide Trafficking from the Endoplasmic Reticulum to the Golgi Apparatus in Mammalian Cells.- Sphingolipid Trafficking.- Current Perspectives on Saccharomyces cerevisiae Sphingolipids.- Part 3: Generation and Degradation of Sphingolipid Signaling Molecules.- Generation of Signaling Molecules by de novo Sphingolipid Synthesis.- Overview of Acid and Neutral Sphingomyelinases in Cell Signaling.- Neutral Ceramidase as an Integral Modulator for the Generation of S1P and S1P-Mediated Signaling.- Activation of Sphingosine Kinase 1.- Ceramide 1-Phosphate.- Sphingosine-1-Phosphate Lyase.- Part 4: Membrane Domain and Biological Function.- Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-Insoluble Membrane Microdomains.- Roles of Membrane Domains in the Signaling Pathway for B Cell Survival.- The Role of Lipid Rafts in Axon Growth and Guidance.- Sphingolipids and Multidrug Resistance of Cancer Cells.- Part 5: Membrane Lipid Domain and Human Pathobiology.- A New Pathological Feature of Insulin Resistance and Type 2 Diadetes: Involvement of Ganglioside GM3 and Membrane Microdomains.- Neuronal Cell Death in Glycosphingolipidoses.- Endocytic Trafficking of Glycosphingolipids in Sphingolipidoses.- Ganglioside and Alzheimer’s

Caracteristici

Reviews exciting new developments in sphingolipid biology/sphingolipidology
The discussion challenges our understanding of how multicellular organisms grow, develop, function, age, and die
Explores sphingolipid biosynthesis, transport and membrane organization/lipid rafts
Offers a genetic approach to understanding the roles of membrane sphingolipid biosynthesis