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Statistical Analysis of Gene Expression Microarray Data: Chapman & Hall/CRC Interdisciplinary Statistics

Editat de Terry Speed
en Limba Engleză Hardback – 26 mar 2003
Although less than a decade old, the field of microarray data analysis is now thriving and growing at a remarkable pace. Biologists, geneticists, and computer scientists as well as statisticians all need an accessible, systematic treatment of the techniques used for analyzing the vast amounts of data generated by large-scale gene expression studies. And there is arguably no group better qualified to do so than the authors of this book.

Statistical Analysis of Gene Expression Microarray Data promises to become the definitive basic reference in the field. Under the editorship of Terry Speed, some of the world's most pre-eminent authorities have joined forces to present the tools, features, and problems associated with the analysis of genetic microarray data. These include::

  • Model-based analysis of oligonucleotide arrays, including expression index computation, outlier detection, and standard error applications
  • Design and analysis of comparative experiments involving microarrays, with focus on \ two-color cDNA or long oligonucleotide arrays on glass slides
  • Classification issues, including the statistical foundations of classification and an overview of different classifiers
  • Clustering, partitioning, and hierarchical methods of analysis, including techniques related to principal components and singular value decomposition

    Although the technologies used in large-scale, high throughput assays will continue to evolve, statistical analysis will remain a cornerstone of their success and future development. Statistical Analysis of Gene Expression Microarray Data will help you meet the challenges of large, complex datasets and contribute to new methodological and computational advances.
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    Specificații

    ISBN-13: 9781584883272
    ISBN-10: 1584883278
    Pagini: 236
    Ilustrații: 99 b/w images, 48 color images, 20 tables and 95 equations
    Dimensiuni: 156 x 234 x 20 mm
    Greutate: 0.51 kg
    Ediția:1
    Editura: CRC Press
    Colecția Chapman and Hall/CRC
    Seria Chapman & Hall/CRC Interdisciplinary Statistics

    Locul publicării:Boca Raton, United States

    Public țintă

    Undergraduate

    Cuprins

    Model-Based Analysis of Oligonucleotide Arrays and Issues in cDNA Microarray Analysis. Design and Analysis of Comparative Microarray Experiments. Classification in Microarray Experiments. Clustering Microarray Data. References. Index.

    Recenzii

    "The 10 authors are among the world's authorities on the statistical analysis of this new class of biotechnology… . What I like best about this stimulating book is that it allows a simplified logical view of large complex multivariate data sets. … I highly recommend this book for library purchase, and for individuals in the field… ."
    - Journal of the Royal Statistical Society, Series A, Vol. 157 (3)


    "Analysis for gene expression data is the latest hot new topic in statistical data analysis...[this book] deals with microarray experiments: design and analysis for a comparative study, classification methods for data analysis, and clustering for data analysis. Scientists whose work concerns this type of data will want to get a copy of the book."
    -Technometrics, 2003


    "…This book is a milestone, documenting major significant advances in the statistical methodology. The four chapters, though independent, share common foci with issues of design, robustness, and the freely available associated software. The statistical ideas are introduced succinctly. The book is especially valuable for research scientists in the field seeking an understanding of the related statistical developments."
    - Short Book Reviews of the ISI

    Descriere

    Written by pre-eminent world authorities in the field, this book is the definitive reference for the statistical analysis of genetic microarray data. Starting from the first steps of genetic microarray data analysis, the book covers the most important topics and common methodologies for analyzing gene expression data, including preprocessing issues, experiment design, classification, and clustering. These discussions provide the tools and guidance needed by biologists, geneticists, and statisticians working in the analysis of genetic data. The presentation level is appropriate for a quantitative biologist and geneticist, as well as for computer scientists working in the area.