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Stroke Genetics de Pankaj Sharma

Stroke Genetics

Editat de Pankaj Sharma, James F. Meschia
en Limba Engleză Mixed media product – 10 apr 2024
This revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined inthe field of inherited stroke.
Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.



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Specificații

ISBN-13: 9783031417764
ISBN-10: 3031417763
Pagini: 624
Ilustrații: XII, 624 p. 50 illus., 32 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 1.09 kg
Ediția:3rd ed. 2024
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Introduction.- Familial stroke epidemiology.- Association study results.- GWAS.- Aneurysms/carvernous/AVM.- ICH/amyloid/microbleeds.- CADASIL.- Fabry.- MELAS.- Sickle.- Other monogenic.- White matter disease.- Carotid atherosclerosis.- Dissection.- Pharmacogenomics.- Non-Caucasian stroke genetics.- Small vessel disease.- Genetics of neuroimaging in stroke.- Cerebrovenous thrombosis.- Ethics.

Notă biografică

Pankaj Sharma, MD, PhD, FRCP, Reader & Consultant Neurologist, Imperial College London & Hammersmith Hospitals, London, UK. He is the Director of the Institute of Cardiovascular Research and also a consultant neurologist at Imperial College Healthcare NHS Trust. He holds a University of London Chair of Neurology at Royal Holloway. He is a former British Heart Foundation Clinician Scientist at Cambridge and a Fulbright Scholar at Harvard Medical School. He holds double doctorates from both the University of Cambridge and University of London. Most recently he led the internationally renowned Imperial College Cerebrovascular Research Unit at Imperial College London. Professor Sharma’s research seeks to use genetics, genomics and proteomics to advance human understanding of cerebrovascular disease in three key areas: prediction, diagnosis and treatment of stroke at the molecular level.  He has a particular interest in the genetics of stroke in ethnic minorities, particularlySouth Asians and Middle Eastern populations. In 2015 he was named the UK’s top Asian Doctor at the British Indian Awards. 
James F. Meschia, MD, Chair, Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. James Meschia is chair of the Department of Neurology at Mayo Clinic Hospital in Jacksonville, Florida and his clinical interests include inherited cerebrovascular diseases, including single-gene disorders, such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), Fabry disease, and sickle cell disease. He graduated from Johns Hopkins University School of Medicine, and went on to complete an internal medicine program in his home state at the University of Colorado. He then completed a neurology residency at Washington University in St. Louis, Missouri, followed by a vascular neurology fellowship at Indiana University. From there he joined Mayo Clinic staff. Dr. Meschia has authored over 200 scientific publications and has served on the editorial boards of Stroke, the European Journal of Neurology, the Journal of Stroke and Cerebrovascular Diseases, and Mayo Clinic Proceedings. He has been a member of several scientific review groups for NINDS and the American Heart Association and a fellow of the Academy of Neurology, American Neurological Association, and the American Heart Association.


Textul de pe ultima copertă

This revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.
Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined in the field of inherited stroke.
Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.

Caracteristici

Includes new chapters on non-Caucasian stroke, advanced imaging and cerebral venous thrombosis Covers important & novel results from large datasets, as genetics continues to advance at an unprecedented rate Free for readers: Additional questions about the book content in the Springer Nature Flashcards app

Recenzii

From the reviews:
“This text reviews genetics of cerebrovascular diseases … . It covers the pathophysiology of occlusive small vessel disease and arteriopathies. It covers Fabry’s Disease, Amyloidosis, MELAS, etc., etc. It covers the imaging, pathophysiology, treatment, and complications for ischemia and hemorrhaging. I recommend this text for neurosurgeons, neurologists, physiologists, genetic investigators, and those with an interest in vascular diseases affecting the cerebrum.” (Joseph J. Grenier, Amazon.com, May, 2014)