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Structural Glycobiology

Editat de Elizabeth Yuriev, Paul A. Ramsland
en Limba Engleză Hardback – 27 sep 2012
Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:
  • X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
  • Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
  • Alternative techniques for yielding structural information on carbohydrates from complex biological samples
  • Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection
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Specificații

ISBN-13: 9781439854600
ISBN-10: 1439854602
Pagini: 348
Ilustrații: 62 black & white illustrations, 37 colour illustrations, 7 black & white tables
Dimensiuni: 156 x 234 x 24 mm
Greutate: 0.64 kg
Ediția:New.
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Academic

Cuprins

Experimental Techniques to Determine Three-Dimensional Structures: Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins. Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions. Electron Cryomicroscopy of Large Glycoprotein Assemblies. Theoretical/Modeling Techniques to Predict Three-Dimensional Structures: Protein–Carbohydrate Interactions: Computational Aspects. Docking of Carbohydrates into Protein Binding Sites. Alternative Approaches for Yielding Detailed Structural Information: Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins. Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins. Carbohydrates in Medicine: Structural Glycobiology: Applications in Cancer Research. Structural Glycobiology: Applications in Organ Transplantation. Structural Glycobiology: Applications in Viral Infection. Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics.

Notă biografică

Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.

Recenzii

"… beautifully illustrated with fine color illustrations … valuable for a wide audience - from graduate students to established researchers involved in studies of carbohydrates as well as for specialists in the other fields - biochemists, clinical chemists and immunologists."
Immunological Investigations, 2013

Descriere

Structural glycobiology is a rapidly growing field of research that examines the structural and functional roles of carbohydrates. This book investigates how research findings have revealed key structural and associated biological information on carbohydrates and glycolipids. The first part presents well-established experimental approaches for the structural determination of carbohydrate–protein complexes and large glycoprotein assemblies. The second section focuses on theoretical and modeling-based approaches. The book then covers alternative and emerging techniques for yielding structural information on carbohydrates from complex biological samples. The final part discusses carbohydrates in medicine.