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Structure and Physics of Viruses: An Integrated Textbook: Subcellular Biochemistry, cartea 68

Editat de Mauricio G. Mateu
en Limba Engleză Hardback – 18 iun 2013
This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.
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Specificații

ISBN-13: 9789400765511
ISBN-10: 9400765517
Pagini: 450
Ilustrații: XIX, 728 p. 177 illus., 122 illus. in color.
Dimensiuni: 155 x 235 x 48 mm
Greutate: 1.59 kg
Ediția:2013
Editura: SPRINGER NETHERLANDS
Colecția Springer
Seria Subcellular Biochemistry

Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Cuprins

Introduction: the structural basis of virus function.- The basic architecture of viruses.- Conventional electron microscopy, cryo-electron microscopy and cryo-electron tomography of viruses.- X-ray crystallography of viruses.- Nuclear magnetic resonance spectroscopy to study virus structure.- Fluorescence, circular dichroism and mass spectrometry as tools to study virus structure.- Combined approaches to study virus structure.- Atomic force microscopy of viruses.- Optical tweezers to study viruses.- Assembly of simple icosahedral viruses.- Structure and assembly of complex viruses.- Nucleic acid packaging in viruses.- Virus maturation.- Virus morphogenesis in the cell: methods and observations.- Virus-receptor interactions and receptor-mediated virus entry into host cells.- Entry of enveloped viruses into host cells: membrane fusion.- Bacteriophage receptor recognition and nucleic acid transfer.- Mechanical properties of viruses.- Theoretical studies on assembly, physical stabilityand dynamics of viruses.- Antiviral agents: Structural basis of action and rational design.- Design of novel vaccines based on virus-like particles or chimeric virions.- Nanoscale science and technology with plant viruses and bacteriophages.

Textul de pe ultima copertă

Structural Virology is today an all-important scientific discipline that permeates most other virological disciplines. The application of physical and physicochemical techniques has led to the determination of the high-resolution molecular structures of many viruses. The interplay of this approach with biochemical and biological approaches has allowed the elucidation of the structural basis of viral function in unprecedented detail. In addition, in the last years theoretical and experimental physicists have begun to tackle a fundamental physics-based approach to study different aspects of the architecture, self-assembly and material properties of virus particles. A new term, Physical Virology, has recently been coined to encompass these and related studies. This approach is beginning to merge with long-standing structural virology approaches to provide a renewed and richer view on viruses, as well as further advances in the fight against viral disease and the applications of viruses in biotechnology and nanotechnology.
Structure and Physics of Viruses is an interdisciplinary textbook in which the rapidly expanding fields of structural and physical virology are dealt with in an integrated way. The authors have attempted to write a book basic enough to be useful to students, as well as advanced and current enough to be useful to senior scientists. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related sciences who share an interest or are actually working on viruses. It is aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. 

Caracteristici

Only integrated book on Structural and Physical Virology An introductory chapter gives essential information that will greatly facilitate understanding of the book by a non-expert reader Organized comprehensive treatment of many subject areas of Structural and Physical Virology

Notă biografică

Mauricio G. Mateu is a Full Professor of Biochemistry and Molecular Biology at the Universidad Autonoma de Madrid (UAM), and a Group Leader at the Centro de Biología Molecular "Severo Ochoa" (Spanish Research Council-UAM). He combined training in biochemistry, molecular virology, and protein engineering in three prestigious laboratories, respectively led by Profs. Severo Ochoa and Esteban Domingo in Madrid, Spain, and Alan R. Fersht in Cambridge, UK, to establish a research line on the structural basis of virus function. His group uses protein engineering and biological, biochemical, and biophysical approaches, including atomic force microscopy, to understand the relationships between atomic structure, conformational stability and dynamics, physical properties, and biological function of viruses. His studies on viruses during the last 35 years have involved multidisciplinary and interdisciplinary collaborations with theoretical and condensed matter physicists, organic chemists, biochemists, structural biologists, biophysicists, and molecular virologists. He is the author of over 150 scientific publications, including over 110 original research articles.