Cantitate/Preț
Produs

SUMO Regulation of Cellular Processes

Editat de Van G. Wilson
en Limba Engleză Paperback – 12 noi 2014
Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (2) 129612 lei  6-8 săpt.
  Springer International Publishing – 20 iun 2018 129612 lei  6-8 săpt.
  SPRINGER NETHERLANDS – 12 noi 2014 154710 lei  38-44 zile
Hardback (1) 130491 lei  6-8 săpt.
  Springer International Publishing – 24 feb 2017 130491 lei  6-8 săpt.

Preț: 154710 lei

Preț vechi: 162853 lei
-5% Nou

Puncte Express: 2321

Preț estimativ în valută:
29607 30723$ 24746£

Carte tipărită la comandă

Livrare economică 13-19 martie

Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9789400791442
ISBN-10: 9400791445
Pagini: 352
Dimensiuni: 155 x 235 x 18 mm
Greutate: 0.49 kg
Ediția:2009
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Research

Descriere

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.

Cuprins

Chapter 1: Introduction to Sumoylation Molecular Functions Chapter 2: SUMO Modification and Transcriptional Regulation Chapter 3: Emerging Roles for SUMO in mRNA Processing and Metabolism Chapter 4: SUMO and Chromatin Remodeling Chapter 5: Functions of SUMO in the Maintenance of Genome Stability Chapter 6: SUMO and Nucleocytoplasmic TransportChapter 7: SUMO Modification of Ion ChannelsChapter 8: The Role of Sumolyation in Metabolic Regulation Cell Growth Regulation Chapter 9: The SUMO Pathway in Mitosis Chapter 10: Wrestling with Chromosomes: The Roles SUMO during Meiosis Chapter 11: Sumoylation in Development and Differentiation Chapter 12: The Role of Sumoylation in Senescence Chapter 13: Sumoylation and Apoptosis Diseases Chapter 14: The Role of Sumoylation in Neurodegenerative Diseases Chapter 15: Sumoylation and its Contribution to Cancer Chapter 16: SUMO4-encoded Genetic Susceptibility to Type 1 Diabetes Chapter 17: Sumoylation in Craniofacial Disorders Chapter 18: Viral Interplay with the Host Sumoylation System

Textul de pe ultima copertă

Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions.
Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention.
While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.

Caracteristici

State of the art, in-depth review of sumoylation
International experts have prepared each chapter
Sumoylation is an essential and critical process that is critical for cell growth and survival
No other available book covers this subject