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Targeted Therapeutics in Melanoma: Current Clinical Oncology

Editat de Thomas F. Gajewski, F. Stephen Hodi
en Limba Engleză Paperback – 3 mar 2014
Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging.
The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies.
This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.
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Specificații

ISBN-13: 9781627038768
ISBN-10: 1627038760
Pagini: 392
Ilustrații: XIV, 378 p.
Dimensiuni: 155 x 235 x 21 mm
Greutate: 0.52 kg
Ediția:2012
Editura: Humana Press Inc.
Colecția Humana
Seria Current Clinical Oncology

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Molecular targets and subtypes in melanoma.- Melanoma genomics.- Predictive biomarkers as a guide to future therapy selection in melanoma.- KIT as a therapeutic target for melanoma.- Targeted inhibition of B-Raf.- The notch and B-catenin pathways.- STAT3 and Src signaling in melanoma.- Targeting the mTOR, PI3K and AKT pathways in melanoma.- Targeting apoptotic pathways in melanoma.- Anti-angiogenesis therapy in melanoma.- Melanoma antigens recognized by T lymphocytes.- Melanoma vaccines.- Adoptive cell therapy for the treatment of metastatic melanoma.- Anti-CTLA-4 monolonal antibodies.- Anti-PD-1 and Anti-B7-H1/PD-L1 monoclonal antibodies.- Treatment of melanoma with agonist immune co-stimulatory agents.- Novel cytokines for immunotherapy of melanoma.- Modulating the tumor microenvironment.

Recenzii

From the reviews:
“This book is a multiauthored edition, with contributors and editors who are experts in their fields regarding new therapeutic approaches for melanoma. … It is a highly technical volume and is directed toward true melanoma mavins, both clinical and laboratory research based, who continue to work at the translational interface. … I recommend this to all those clinical, translational, and laboratory investigators committed to moving the field forward in the development of treatment for melanoma.” (Janice P. Dutcher, Medical Oncology, Vol. 30, 2013)

Textul de pe ultima copertă

Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging.
The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies.
This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.

Caracteristici

Describes both established signal transduction inhibitors as well as emerging molecularly-guided immunotherapies Places exciting developments in basic biological understanding into a practical clinical context The first book on melanoma devoted entirely to targeted therapeutics Includes the most up-to-date data from current clinical Phase I-III trials Written by high-profile authors representing the world’s leaders in their field Includes supplementary material: sn.pub/extras