Ten Years of Progress in GW/P Body Research
Editat de Edward K. L. Chan, Marvin J. Fritzleren Limba Engleză Paperback – 29 ian 2015
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Specificații
ISBN-13: 9781493902514
ISBN-10: 1493902512
Pagini: 288
Ilustrații: XII, 276 p.
Dimensiuni: 155 x 235 x 15 mm
Greutate: 0.41 kg
Ediția:2013
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1493902512
Pagini: 288
Ilustrații: XII, 276 p.
Dimensiuni: 155 x 235 x 15 mm
Greutate: 0.41 kg
Ediția:2013
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
Preface.- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology.- The Discovery of GW Bodies.- The Discovery and Analysis of P Bodies.- Autoantibodies to Argonaute 2 (Su antigen).- GW/P Bodies and Autoimmune Disease.- Function of GW182 and GW Bodies in siRNA and miRNA Pathways.- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs.- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue.- The Role of GW182 Proteins in miRNA-mediated Gene Silencing.- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities.- Deadenylation and P-bodies.- Relationship of GW/P-bodies with Stress Granules.- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies.- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182.- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.- Index.
Caracteristici
Provides a history of the discovery of cytoplasmic structures Serves as a 10 year review of researchers' current knowledge in subcellular structures This book appeals to cell biologists, investigators involved in microRNA and post-translational regulation of gene expression research, clinical scientiss, and industries that are now using knowledge of the miRNA pathway to design and develop new therapeutics for a broad range of conditions Includes supplementary material: sn.pub/extras