Textbook of Personalized Medicine

en Limba Engleză Paperback – 7 dec 2021

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.
This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.
Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

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Specificații

ISBN-13: 9783030620820
ISBN-10: 3030620824
Pagini: 744
Ilustrații: XLIII, 744 p. 41 illus., 5 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 1.71 kg
Ediția:3rd ed. 2021
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Preface to the 3rd edition

1 Basic Aspects
Definition of personalized medicine
History of medical concepts relevant to personalized medicine
Molecular biological basis of personalized medicine
Basics technologies for developing personalized medicine
‘Omics’ and personalized medicine
Conventional medicine versus personalized medicine
Personalized medicine and evidence-based medicine
Role of genetics in future approaches to healthcare
Role of systems biology in personalized medicine
Synthetic biology and development of personalized medicines Personalized digital medicine
A personalized approach to environmental factors in disease
Reclassification of diseases
Translational science and personalized medicine
Personalization of multimodal therapies

2 Molecular Diagnostics in Personalized Medicine
Introduction
Molecular diagnostic technologies
               Sequencing
Biochips and microarrays
SNP genotyping
Detection of copy number variations
Study of rare variants in pinpointing disease-causing genes
Optical Mapping
Proteomics in molecular diagnosis
Role of nanobiotechnology in molecular diagnostics
Role of biosensors in personalized medicine
Gene expression profiling
Molecular imaging and personalized medicine
Combination of diagnostics and therapeutics
Point-of-care diagnosis
Genetic testing for disease predisposition
Combination of diagnostics with therapeutics
Future of molecular diagnostics in personalized medicine

3 Role of Biomarkers in Personalized Medicine

4 Pharmacogenetics
Basics of pharmacogenetics
Role of molecular diagnostics in pharmacogenetics
Role of pharmacogenetics in pharmaceutical industry
Clinical implications of pharmacogenetics
Limitations of pharmacogenetics
Pharmacoepigenomics vs pharmacogenetics in drug safety
Future role of pharmacogenetics in personalized medicine

5 Pharmacogenomics
Introduction
Basics of pharmacogenomics
Pharmacogenomics and drug discovery
Pharmacogenomics and clinical trials
Pharmacogenomic aspects of major therapeutic areas
Current status and future prospects of pharmacogenomics

6 Role of Pharmacoproteomics
Basics of proteomics
Proteomic approaches to the study of pathophysiology of diseases
Proteomic technologies for drug discovery and development
Applications of pharmacoproteomics in personalized medicine

7 Role of Metabolomics in Personalized Medicine
Metabolomics and metabonomics
Metabolomics bridges the gap between genotype and phenotype
Metabolomics, biomarkers and personalized medicine
Metabolomic technologies
Pharmacometabonomics
Metabonomic technologies for toxicology studies
Metabonomics/metabolomics and personalized nutrition
Metabolomics for personalized medicine

8 Role of Nanobiotechnology in Development of Personalized Medicine

9 Personalized Biological Therapies
Introduction
Recombinant human proteins
Therapeutic monoclonal antibodies
Cell therapy
Gene therapy
Personalized vaccines
Antisense therapy

10 Personalized Non-pharmacological Therapies
Introduction
Acupuncture
Personalized hyperbaric oxygen therapy
Personalized nutrition
Personalized physical exercise
Personalized surgery

11 Personalized Therapy of Cancer

12 Personalized Therapy of Neurological Disorders

13 Personalized Therapy of Psychiatric Disorders

14 Personalized Therapy of Cardiovascular Disorders

15 Personalized Therapy of Pulmonary Disorders

16 Personalized Therapy Infectious Diseases

17 Personalized Approaches in Immunology
18 Personalized Management of Genetic Disorders

19 Personalized Management of Miscellaneous Disorders
Personalized management of DNA repair disorders
Personalized preventive medicine
Personalized management of ophthalmic disorders
Personalized management of skin disorders
Personalized urology
Personalized therapy of rheumatoid arthritis
Personalized management of obesity
Personalized management of diabetes Management of genetic disorders
Personalized management of gastrointestinal disorders
Personalized approaches to improve organ transplantation
Personalized approaches to addiction
Personalized geriatrics
Personalized pediatrics
Personalized nephrology
Personalized gynecology

20 Development of Personalized Medicine
Introduction
Non-genomic factors in the development of personalized medicine
Players in the development of personalized medicine
Role of genetic banking systems and databases
Role of bioinformatics in development of personalized medicine
Integration of technologies for personalized medicine
Global scope of personalized medicine
Advantages of personalized medicine
Limitations of personalized medicine
Future of personalized medicine

21 Ethical Aspects of Personalized Medicine

22 Legal Aspects of Personalized Medicine

23 Regulatory Aspects of Personalized Medicine
FDA and personalized medicine
FDA and molecular diagnostics in relation to personalized medicine
Regulatory aspects of pharmacogenetics
Regulation of direct-to-consumer genetic testing
FDA and pharmacogenomics
FDA and predictive medicine

24 Economics of Personalized Medicine

25 Future of Personalized Medicine

Notă biografică

Prof. K. K. Jain MD, FRACS, FFPM
Jain PharmaBiotech
Blaesiring 7
CH-4057 Basel, Switzerland

Textul de pe ultima copertă

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.
This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.
Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Caracteristici

Thoroughly updated new edition
Covers all aspects of personalized medicine
Serves as a convenient source of information for physicians, scientists, decision makers in the bio-pharmaceutical and healthcare industries

Descriere

Descriere de la o altă ediție sau format:
Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic.
There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

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