The 4-Quinolones: Anti Bacterial Agents in Vitro: Antibacterial Agents in Vitro: Springer Series in Applied Biology
Editat de Geoff C. Crumplinen Limba Engleză Paperback – 12 apr 2012
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Specificații
ISBN-13: 9781447134510
ISBN-10: 1447134516
Pagini: 292
Ilustrații: XIV, 276 p.
Dimensiuni: 170 x 244 x 15 mm
Greutate: 0.47 kg
Ediția:Softcover reprint of the original 1st ed. 1990
Editura: SPRINGER LONDON
Colecția Springer
Seria Springer Series in Applied Biology
Locul publicării:London, United Kingdom
ISBN-10: 1447134516
Pagini: 292
Ilustrații: XIV, 276 p.
Dimensiuni: 170 x 244 x 15 mm
Greutate: 0.47 kg
Ediția:Softcover reprint of the original 1st ed. 1990
Editura: SPRINGER LONDON
Colecția Springer
Seria Springer Series in Applied Biology
Locul publicării:London, United Kingdom
Public țintă
ResearchCuprins
1 Quinolones as Broad-Spectrum Agents.- 2 Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency.- 3 The Influence of Oxygen upon Bactericidal Potency.- 4 Interactions of 4-Quinolones with Other Agents — the Importance in Assessing Practical Antibacterial Potency.- 5 Molecular Effects of 4-Quinolones upon DNA Gyrase.- 6 Mechanisms of Killing of Bacteria by 4-Quinolones.- 7 Use of an in vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase.- 8 Comparisons of DNA Gyrases from Different Species.- 9 Structure-activity Relationships of Fluoro-4-Quinolones.- 10 Aspects of Quinolone-DNA Interactions.- 11 Selective Toxicity: the Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases.- 12 In vitro Genotoxity Assessment and the Effects of 4-Quinolones upon Human Cells.- 13 Mechanisms of Bacterial Resistance to 4-Quinolones.- 14 In vitro and in vivo Mutation Frequencies to Resistance — do they Correlate in the Long Term?.- 15 Measurement of the Frequency of Mutation to Resistance — the Importance of Testing under Physiological Conditions.- 16 Plasmid-borne Resistance to 4-Quinolones — a Real or an Apparent Absence?.- Poster Presentations.- Anaerobiosis and staphylococcal resistance to certain 4-quinolones.- Gram Negative Mutants Resistant to 4-Quinolones: Are they Competent Pathogens?.- Quinolone-Resistant E. Coli Mutants Overproduce a 60 kDa Protein Highly Homologous to GroEL.