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The Essential Guide to N-of-1 Trials in Health

Editat de Jane Nikles, Geoffrey Mitchell
en Limba Engleză Hardback – 14 oct 2015
N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs.  They have the potential to revolutionize the way clinical medicine is practiced.
Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials.
Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more.  Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.
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Specificații

ISBN-13: 9789401771993
ISBN-10: 9401771995
Pagini: 245
Ilustrații: XI, 245 p.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.65 kg
Ediția:1st ed. 2015
Editura: SPRINGER NETHERLANDS
Colecția Springer
Locul publicării:Dordrecht, Netherlands

Public țintă

Professional/practitioner

Cuprins

Preface.- Introduction.- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences.- N-of-1 trials in medical contexts.- Aggregated N-of-1 trials.- Methodological considerations for N-of-1 trials.- Randomization, allocation concealment and blinding.- Data collection and quality control.- Individual reporting of N-of-1 trials to patients and clinicians.- Assessing and reporting adverse events.- Research ethics and N-of-1 trials.- Statistical analysis of N-of-1 trials.- The economics of N-of-1 trials.- Reporting N-of-1 trials to professional audiences.- Single patient open trials.- Systematic review and meta-analysis using N-of-1 trials.- Where are N-of-1 trials headed?- Index.

Recenzii

“This is a philosophical rethinking of thelimitations of randomized controlled trials and the value of cross-overexperiments conducted with a single patient. … This is a book for experiencedclinicians who are knowledgeable about current evidence-based treatmentmodalities and who can objectively recognize when to consider different optionsfor treatment.” (Vincent F. Carr, Doody’s Book Reviews, January 2016)

Textul de pe ultima copertă

N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs.  They have the potential to revolutionize the way clinical medicine is practiced.
Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials.
Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Caracteristici

Stand alone chapters covering every aspect of N-of-1 trials Each easy to read chapters written by experts How-to guides for busy clinicians