The Genetics of Complex Thyroid Diseases
Editat de T. Akamizu, M. Kasuga, T. F. Daviesen Limba Engleză Hardback – 31 dec 2001
Toate formatele și edițiile | Preț | Express |
---|---|---|
Paperback (1) | 358.27 lei 6-8 săpt. | |
Springer – 19 noi 2013 | 358.27 lei 6-8 săpt. | |
Hardback (1) | 364.91 lei 6-8 săpt. | |
Springer – 31 dec 2001 | 364.91 lei 6-8 săpt. |
Preț: 364.91 lei
Preț vechi: 384.11 lei
-5% Nou
Puncte Express: 547
Preț estimativ în valută:
69.84€ • 72.54$ • 58.01£
69.84€ • 72.54$ • 58.01£
Carte tipărită la comandă
Livrare economică 04-18 februarie 25
Preluare comenzi: 021 569.72.76
Specificații
ISBN-13: 9784431703259
ISBN-10: 443170325X
Pagini: 236
Ilustrații: XI, 222 p.
Dimensiuni: 155 x 235 x 18 mm
Greutate: 0.51 kg
Ediția:2002
Editura: Springer
Colecția Springer
Locul publicării:Tokyo, Japan
ISBN-10: 443170325X
Pagini: 236
Ilustrații: XI, 222 p.
Dimensiuni: 155 x 235 x 18 mm
Greutate: 0.51 kg
Ediția:2002
Editura: Springer
Colecția Springer
Locul publicării:Tokyo, Japan
Public țintă
ResearchDescriere
The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin guished researchers from the United States, the United Kingdom, France, Ger many, Italy, and Japan were invited. Each presentation precipitated intense dis cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.
Cuprins
1 Autoimmune Thyroid Diseases.- Genetic dissection of familial autoimmune thyroid diseases using whole genome screening.- Genome screening for Graves’ disease susceptibility loci in U.K. families.- The involvement of the HLA region in genetic susceptibility to Grave s’ disease.- HLA and autoimmune thyroid diseases.- What can we learn from the genetics of diabetes?.- The genomic biology of the human chromosome 2q33 costimulatory receptor region.- CTLA-4 gene in the pathogenesis of Graves’ disease.- The evolving role of CTLA-4 in the genetic predisposition to AITD.- Association of AITD with microsatellite markers for TSHR and CTLA-4 in Japanese patients.- 2 Familial Thyroid Cancers.- Familial non medullary thyroid cancer.- Cowden disease and the PTEN/MMACI gene.- Molecular mechanisms of RET activation in human neoplasia.- Lessons from Chernobyl; need for molecular epidemiology of childhood thyroid cancer.- Genetic events in radiation-induced thyroid cancer.- Keyword Index.
Caracteristici
Focusing on the autoimmune thyroid diseases and familial thyroid cancers