The Hsp60 Chaperonin: SpringerBriefs in Molecular Science
Autor Peter Brossen Limba Engleză Paperback – 16 dec 2015
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Specificații
ISBN-13: 9783319260860
ISBN-10: 3319260863
Pagini: 90
Ilustrații: XV, 85 p. 19 illus., 4 illus. in color.
Dimensiuni: 155 x 235 x 5 mm
Greutate: 0.15 kg
Ediția:1st ed. 2015
Editura: Springer International Publishing
Colecția Springer
Seriile SpringerBriefs in Molecular Science, Protein Folding and Structure
Locul publicării:Cham, Switzerland
ISBN-10: 3319260863
Pagini: 90
Ilustrații: XV, 85 p. 19 illus., 4 illus. in color.
Dimensiuni: 155 x 235 x 5 mm
Greutate: 0.15 kg
Ediția:1st ed. 2015
Editura: Springer International Publishing
Colecția Springer
Seriile SpringerBriefs in Molecular Science, Protein Folding and Structure
Locul publicării:Cham, Switzerland
Public țintă
ResearchCuprins
Introduction.- Historical sketch of the discovery and recognition of the function of chaperonins.- Molecular structure of chaperonins.- Folding by enclosure in the chaperonin cavity.- Evolutionary origins and family relations.- Chaperoning mechanisms: folding helpers, folding protectors or misfolding blockers?.- Sequence variations in proteins affecting chaperonin dependence.- Genetic organization of type I chaperonin genes.- Regulation of type I chaperonin gene expression.- Subcellular localization.- Posttranslational modifications.- Variations in Hsp60 and Hsp10 in humans.- Type I chaperonins are essential for cell viability and mutations cause deficiency phenotypes.- Human diseases caused by genetic mutations in the Hsp60/Hsp10 system.- Molecular investigations of disease mechanisms.- Molecular investigations of disease mechanisms.- Outlook.
Textul de pe ultima copertă
In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
Caracteristici
Describes the basics of Hsp60 chaperonin structure Outlines the function of Hsp60 as a folding helper Explains the multiple roles of Hsp60 for cellular systems and regulatory pathways Includes supplementary material: sn.pub/extras