Three diverse women come together. With their dynamism and inventive thinking, they've created a herbal nursery in the remote Karoo of South Africa. In this harsh, austere, but beautiful land, they nurture a successful business. Annette Padstow is the mistress of a large working farm, married to Simon. Theirs has been a lasting, passionate marriage. Her three children, now away at boarding school, have left a gap in her life. Marilese van Acht, a widow in her sixties, is looking for new horizons to fill her days. Sarie Davids is a herbalist, poor and battling to survive in a dusty, run-down township. Sarie has secrets of powerful remedies. She produces a tincture that arrests and even seems to reverse the curse of memory loss. The potential is huge. Philip Marshall, a local lawyer, greedy and unscrupulous, hears about this miracle cure and wants it for his own. The ladies of Samarann pit their wits against his treachery, and the tension mounts as he gets more and more desperate, until tragedy occurs and lives are changed forever.