The Caucasian population of the United States has been in intimate contact with the aborigines for a period of not less than two hundred and fifty years. In certain sections, as in Florida and New Mexico, this contact has been for a still greater period; but claiming no earlier date than the settlement of New England, it will be seen that the white race has been slow to learn or the red man has been skillful in withholding knowledge which, if imparted, would have lessened friction and done much to preserve and assimilate a race that, in spite of some serious defects of character, will for all time to come be looked upon as "the noble savage." Recent deplorable occurrences in the country of the Dakotas have emphasized our ignorance and made clear to the minds of all thinking people that, notwithstanding the acceptance by the native tribes of many of the improvements in living introduced by civilization, the savage has remained a savage, and is still under the control of an influence antagonistic to the rapid absorption of new ideas and the adoption of new customs. Who, and what are the medicine-men (or medicine-women), of the American Indians? What powers do they possess in time of peace or war? How is this power obtained, how renewed, how exercised? What is the character of the remedies employed? Are they pharmaceutical, as we employ the term, or are they the superstitious efforts of empiricists and charlatans, seeking to deceive and to misguide by pretended consultations with spiritual powers and by reliance upon mysterious and occult influences? Such a discussion will be attempted in this paper, which will be restricted to a description of the personality of the medicine-men, the regalia worn, and the powers possessed and claimed.