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The Quasispecies Equation and Classical Population Models: Probability Theory and Stochastic Modelling, cartea 102

Autor Raphaël Cerf, Joseba Dalmau
en Limba Engleză Paperback – aug 2023
This monograph studies a series of mathematical models of the evolution of a population under mutation and selection. Its starting point is the quasispecies equation, a general non-linear equation which describes the mutation-selection equilibrium in Manfred Eigen’s famous quasispecies model. A detailed analysis of this equation is given under the assumptions of finite genotype space, sharp peak landscape, and class-dependent fitness landscapes. Different probabilistic representation formulae are derived for its solution, involving classical combinatorial quantities like Stirling and Euler numbers.
It is shown how quasispecies and error threshold phenomena emerge in finite population models, and full mathematical proofs are provided in the case of the Wright–Fisher model. Along the way, exact formulas are obtained for the quasispecies distribution in the long chain regime, on the sharp peak landscape and on class-dependent fitness landscapes.
Finally, several other classical population models are analyzed, with a focus on their dynamical behavior and their links to the quasispecies equation. 
This book will be of interest to mathematicians and theoretical ecologists/biologists working with finite population models.


 
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Specificații

ISBN-13: 9783031086656
ISBN-10: 3031086651
Pagini: 242
Ilustrații: X, 242 p. 1 illus.
Dimensiuni: 155 x 235 mm
Greutate: 0.36 kg
Ediția:1st ed. 2022
Editura: Springer International Publishing
Colecția Springer
Seria Probability Theory and Stochastic Modelling

Locul publicării:Cham, Switzerland

Cuprins

1. Introduction.- Part I.Finite Genotype Space.- 2. The Quasispecies equation.- 3. Non-Overlapping Generations.- 4. Overlapping Generations.- 5. Probabilistic Representations.- Part II. The Sharp Peak Landscape.- 6. Long Chain Regime.- 7. Error Threshold and Quasispecies.- 8. Probabilistic Derivation.- 9. Summation of the Series.- 10. Error Threshold in Infinite Populations.- Part III. Error Threshold in Finite Populations.- 11.Phase Transition.- 12. Computer Simulations.- 13. Heuristics.- 14. Shape of the Critical Curve.- 15. Framework for the Proofs.- Part IV. Proof for Wright-Fisher.- 16. Strategy of the Proof.- 17. The Non-Neutral Phase M.- 18. Mutation Dynamics.- 19. The Neutral Phase N.- 20. Synthesis.- Part V. Class-Dependent Fitness Landscapes.- 21. Generalized Quasispecies Distributions.- 22. Error Threshold.- 23. Probabilistic Representation.- 24. Probabilistic Interpretations.- 25. Infinite Population Models.- Part VI. A Glimpse at the Dynamics.- 26. Deterministic Level.- 27. From Finite to Infinite Population.- 28. Class-Dependent Landscapes.- A. Markov Chains and Classical Results.- References.- Index.

Recenzii

“This book is a welcome and timely addition to the existing literature on rigorous mathematical analysis of various genetics models, with a special focus on a careful understanding of the impact of stochastic effects. The book is written with the potential reader in mind, such that it is a real pleasure to read. It should be interesting to anyone working at the interface of mathematics and population genetics.” (Artem S. Novozhilov, Mathematical Reviews, August, 2023)

“The text is written in an easy-to-read style and is suitable for use in various courses, including probability theory, Markov chains, mathematical ecology and population dynamics. The book can be expected to provide several ideas for further investigation of finite population models.” (Attila Dénes, zbMATH 1507.92072, 2023)

Notă biografică



Textul de pe ultima copertă

This monograph studies a series of mathematical models of the evolution of a population under mutation and selection. Its starting point is the quasispecies equation, a general non-linear equation which describes the mutation-selection equilibrium in Manfred Eigen’s famous quasispecies model. A detailed analysis of this equation is given under the assumptions of finite genotype space, sharp peak landscape, and class-dependent fitness landscapes. Different probabilistic representation formulae are derived for its solution, involving classical combinatorial quantities like Stirling and Euler numbers. It is shown how quasispecies and error threshold phenomena emerge in finite population models, and full mathematical proofs are provided in the case of the Wright–Fisher model. Along the way, exact formulas are obtained for the quasispecies distribution in the long chain regime, on the sharp peak landscape and on class-dependent fitness landscapes.
Finally, several other classical population models are analyzed, with a focus on their dynamical behavior and their links to the quasispecies equation. 
This book will be of interest to mathematicians and theoretical ecologists/biologists working with finite population models.

Caracteristici

This book provides an in-depth study of the Eigen's Quasispecies equation in the context of population models. The case of the Wright-Fisher model is treated in detail, other classical population models are also discussed. Contains a foreword by Michel Benaïm.