Cantitate/Preț
Produs
Total produse
Vezi coșul
The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity de Tjitske Heida

The Subthalamic Nucleus: Part II: Modelling and Simulation of Activity: Advances in Anatomy, Embryology and Cell Biology, cartea 199

Autor Tjitske Heida, Enrico Marani, Kamen G. Usunoff
en Limba Engleză Paperback – 23 iul 2008
Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson’s disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.
Citește tot Restrânge

Din seria Advances in Anatomy, Embryology and Cell Biology

  • 5% Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells
    Preț: 110289 lei
  • 5% Regulation of Implantation and Establishment of Pregnancy in Mammals: Tribute to 45 Year Anniversary of Roger V. Short's "Maternal Recognition of Pregnancy"
    Preț: 69392 lei
  • 15% The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy
    Preț: 61305 lei
  • Metallothioneins in Normal and Cancer Cells
    Preț: 36747 lei
  • 15% Focus on Bio-Image Informatics
    Preț: 62056 lei
  • 5% Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy
    Preț: 98632 lei
  • 15% The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium
    Preț: 66387 lei
  • 15% The Centrosome and its Functions and Dysfunctions
    Preț: 55528 lei
  • 15% Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body
    Preț: 55844 lei
  • 5% Ergebnisse der Anatomie und Entwicklungsgeschichte / Reviews of Anatomy Embryology and Cell Biology / Revues D’anatomie et de Morphologie Expérimentale
    Preț: 37870 lei
  • Licht- und elektronenmikroskopische Untersuchungen am Subcommissuralorgan der Maus
    Preț: 39329 lei
  • Die Schlüpfdrüse der Geburtshelferkröte (Alytes o. obstetricans [LAURENTI]) und anderer Froschlurche
    Preț: 39292 lei
  • 5% The Development of the Rat Hypothalamus
    Preț: 104929 lei
  • 5% The Female Genital Tract of the Shrew Crocidura russula
    Preț: 67847 lei
  • 5% The Mammalian Carotid Body
    Preț: 67935 lei
  • 5% The Motoneuronal Organization of the Spinal Accessory Nuclear Complex
    Preț: 34417 lei
  • 5% The Development of the Chondrocranium of Melopsittacus undulatus
    Preț: 67795 lei
  • 5% Photoperiod and Testicular Function in Phodopus sungorus
    Preț: 67847 lei
  • 5% Functional Morphology of the Golgi Apparatus
    Preț: 34591 lei
  • 5% The Brain Stem in a Lizard, Varanus exanthematicus
    Preț: 68462 lei
  • 15% The Distal Nephron in the Kidney of Fishes
    Preț: 61145 lei
  • 15% Early Development of the Shoulder Girdle and Sternum in Marsupials (Mammalia: Metatheria)
    Preț: 60783 lei
  • 15% Functional Morphology of the Tail Apparatus of the Pigeon (Columba livia)
    Preț: 60940 lei
  • 15% Neurotransmission in the Hippocampus
    Preț: 60846 lei
  • 5% Vertebral Malformations
    Preț: 67989 lei
  • 15% The Development of the Chondrocranium of Gallus gallus
    Preț: 60722 lei
  • 5% Human Mast Cells
    Preț: 68040 lei
  • 5% Granulated Metrial Gland Cells
    Preț: 68059 lei
  • 5% A Fifteen-somite Human Embryo
    Preț: 34611 lei
  • 5% The Anatomical Substrate for Telencephalic Function
    Preț: 68094 lei
  • 5% The Development of the Larval Pigment Patterns in Triturus alpestris and Ambystoma mexicanum
    Preț: 68040 lei
  • 5% Axonal Regeneration in the Mammalian Central Nervous System: A Critique of Hypotheses
    Preț: 68128 lei
  • 5% Histophysiology of the Circulating Platelet
    Preț: 67970 lei
  • 5% The Human Substantia Nigra and Ventral Tegmental Area: A Neuroanatomical Study with Notes on Aging and Aging Diseases
    Preț: 68199 lei
  • 5% Cell Proliferation and Cytogenesis in the Mouse Hippocampus
    Preț: 67900 lei
  • 5% The Early Development of the Neopallial Wall and Area Choroidea in Fetal Rats: A Light and Electron Microscopic Study
    Preț: 67847 lei
  • 5% The Functional Morphology of the Human Endometrium and Decidua
    Preț: 68004 lei
  • 15% Development of the Digestive System in the North American Opossum (Didelphis virginiana)
    Preț: 61113 lei
  • 15% Cytokeratins in Intracranial and Intraspinal Tissues
    Preț: 60722 lei
  • 5% The Amniotic Fluid Compartment: The Fetal Habitat
    Preț: 68004 lei
  • 5% The Efferent System of Cranial Nerve Nuclei: A Comparative Neuromorphological Study
    Preț: 67935 lei
  • 5% Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches
    Preț: 68393 lei
  • 5% Histophysiology of the Obesity-Diabetes Syndrome in Sand Rats
    Preț: 67865 lei
  • 15% Comparative Anatomy of the External and Middle Ear of Palaeognathous Birds
    Preț: 60925 lei
  • 15% Normal Testicular Descent and the Aetiology of Cryptorchidism
    Preț: 60531 lei
  • 15% The Anatomy of Manual Dexterity: The New Connectivity of the Primate Sensorimotor Thalamus and Cerebral Cortex
    Preț: 60957 lei
  • 15% The Influence of Ethyl Alcohol on the Development of the Chondrocranium of Gallus gallus
    Preț: 60878 lei
  • 15% The Projections to the Spinal Cord of the Rat During Development: A Timetable of Descent
    Preț: 60971 lei
  • 18% The Trigeminal System in Man
    Preț: 74444 lei
  • 15% The Role of Microenvironment in Axonal Regeneration: Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix
    Preț: 60659 lei

Preț: 74444 lei

Preț vechi: 90785 lei
-18% Nou

Puncte Express: 1117
Preț estimativ în valută:
14248€ • 15031$ • 11873£

Carte tipărită la comandă

Livrare economică 02-16 ianuarie 25

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783540794615
ISBN-10: 3540794611
Pagini: 130
Ilustrații: XIV, 88 p. 54 illus., 4 illus. in color.
Dimensiuni: 155 x 235 x 8 mm
Greutate: 0.2 kg
Ediția:2008
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Advances in Anatomy, Embryology and Cell Biology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

The Basal Ganglia.- STN Activity Recorded in Vitro: Brain Slices.- STN Activity Recorded in Vitro: Dissociated Cell Cultures.- STN Cell Models and Simulation of Neuronal Networks.- Comparison of Part I and Part II.

Textul de pe ultima copertă

This monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson’s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsukaand Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results.