In an inexplicable worldwide event, forty-three extraordinary children were spontaneously born by women who'd previously shown no signs of pregnancy. Millionaire inventor Reginald Hargreeves adopted seven of the children; when asked why, his only explanation was, 'To save the world.' These children form a dysfunctional family with bizarre superpowers. Nearly a decade after their first mission, the team disbands, but when Hargreeves unexpectedly dies, the siblings reunite just in time to save the world once again.