In this book the author puts forward an agenda to enhance intelligence and longevity in humans, select animal species (including dogs, dolphins and elephants), and machines. This effort would extend over 1,000 years or 40 human generations. Enhancements of IQ and longevity in humans would involve both environmental and genetic improvements in membership IQ and longevity. The goal would be a mean IQ of 145 and an average longevity of 100 years in human Uplift Project members by the end of these 1,000 years. Given that Uplift Project members will probably at project outset have better than average IQ and life expectancy, this could involve as little as a two standard deviations increase in IQ (30 points) and one standard deviation increase in longevity (20 years) over these 1,000 years.The Uplift Project would also expand human, animal and machine membership not only across the planet, but to the moon, Mars, and space colonies.