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The Value of BCG and TNF in Autoimmunity

Editat de Denise Faustman
en Limba Engleză Paperback – 19 iul 2018
The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.


  • Brings a different perspective on treatment approaches for certain autoimmune conditions
  • Gives insight into the how the BCG vaccine impacts gene expression and the durability of the BCG vaccines in long lasting clinic effects
  • Discusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatment
  • Covers new topics, such as the Epigenetics of tuberculosis, BCG in neurological disease, BCG in early childhood and allergy, BCG in large prevention trials, Gene expression of BCG and re-methylation of genes, and more
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Specificații

ISBN-13: 9780128146033
ISBN-10: 0128146036
Pagini: 200
Dimensiuni: 152 x 229 mm
Ediția:2
Editura: ELSEVIER SCIENCE

Public țintă

This book is intended for clinical Researchers and scientists working in the fields of autoimmunity, immunology, biochemistry and genetics. Our experience with the first Edition was the book found a significant audience among disease advocates as well.

Cuprins

1. BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease
2. The Potential of TNF Induction from BCG for the Treatment of Type 1 Diabetes
3. Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation
4. Host Epigenetic Modifications in Mycobacterium Tuberculosis Infection: A Boon or Bane
5. Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy
6. The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity
7. BCG in Neonatals
8. Epigenetic Rewiring of Monocytes in BCG Vaccination
9. Mycobacteria, Immunoregulation and Autoimmunity
10. mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium Tuberculosis Infection and BCG Vaccination
11. The Role of Maternal Priming and Boosting for the Non-Specific Effects of BCG Vaccine