This book constitutes the thoroughly refereed post-conference proceedings of the 5th Conference on Theory of Quantum Computation, Communication, and Cryptography, TQC 2010, held in Leeds, UK, in April 2010.The 15 revised papers presented were carefully selected during two rounds of reviewing and improvement. Focussing on theoretical aspects of quantum computation, quantum communication, and quantum cryptography - part of a larger interdisciplinary field embedding information science in a quantum mechanical framework - the papers present current original research. Topics addressed include quantum algorithms, models of quantum computation, quantum complexity theory, simulation of quantum systems, quantum cryptography, quantum communication, quantum estimation and measurement, quantum noise, quantum coding theory, fault-tolerant quantum computing, and entanglement theory.