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Thyroid and Heart Failure: From Pathophysiology to Clinics

Editat de Giorgio Iervasi Cuvânt înainte de Paul W. Ladenson Editat de Alessandro Pingitore Cuvânt înainte de Attilio Maseri
en Limba Engleză Paperback – 21 oct 2010
Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.
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Specificații

ISBN-13: 9788847015692
ISBN-10: 8847015693
Pagini: 288
Ilustrații: XXI, 266 p.
Dimensiuni: 193 x 260 x 15 mm
Greutate: 0.68 kg
Ediția:Softcover reprint of hardcover 1st ed. 2009
Editura: Springer
Colecția Springer
Locul publicării:Milano, Italy

Public țintă

Professional/practitioner

Cuprins

Heart Failure and Thyroid: General Aspects.- Heart Failure: From Epidemiology to Pathophysiology.- Neuroendocrine Control of the Cardiovascular System in Heart Failure.- Cardiac Morphology and Function in Mild Hypothyroidism.- Cardiovascular Hemodynamics and Work Capacity in Thyroid Dysfunction.- Basic Aspects of Thryroid Hormone and Cardiovascular System Interrelationships in Normal and in Failing Heart.- Mechanism of Action of Thyroid Hormone on the Cardiac Vascular System.- Cardiac Functional Effects of 3-iodothyronamine, a New Endogenous Thyroid Hormone Derivative.- Cardiac Thyroid-Hormone Deiodinative Pathways in Ventricular Hypertrophy and Heart Failure.- Thyroid Hormone Receptor Signaling in Normal and Failing Heart.- Pharmacological Effects of Amiodarone and Dronedarone on Cardiac Thyroid Hormone Receptors.- Changes in Thyroid Hormone Metabolism and Gene Expression in the Failing Heart: Therapeutic Implications.- Thyroid-Hormone-Regulated Cardiac Metabolism in Normal and Failing Heart.- Cardiac Myocyte and Vascular Remodeling in Altered Thyroid Conditions.- Thyroid Hormone and Ischemic Myocardium.- Clinical Aspects.- Thyroid and Cardiovascular Risk.- Relationship Between Subclinical Thyroid Dysfunction and Heart Failure and Mortality.- Low Triiodothyronine Syndrome as a Powerful Predictor of Death in Heart Failure.- Thyroid, Renal Function, and Cardiac Outcome.- Low Triiodothyronine Syndrome and Depression in Patients with Chronic Heart Failure.- Treatment: Present and Future Options.- Treatment Options for Primary Thyroid Disease in Patients with Heart Failure.- Synthetic Thyroid Hormone and Thyroid Hormone Analogues for Treatment of Heart Failure.- Thyroid Hormone Supplementation for Infants and Children Undergoing Cardiopulmonary Bypass for Cardiac Surgery.-New Approaches for Treating Heart Disease by Modulating Thyroid Hormone Signaling Using Gene Therapy Approaches.

Recenzii

From the reviews:
"This book presents contributions from preeminent scientists, both bench and clinical, to summarize the important interplay between the failing heart and the thyroid gland. This book attempts to gather the most up-to-date information about the pathophysiological and clinical significance of thyroid disease in relationship to heart failure. Students, physicians in training, and clinicians involved in the management of heart failure patients are the intended readers. … This is a well designed book for caregivers whose primary focus is heart failure." (David J. Homan, Doody’s Review Service, September, 2009)

Textul de pe ultima copertă

Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.

Caracteristici

Volume describes the relationship between the altered thyroid hormone profile and the prognosis of patients with heart failure, a novel and controversial issue of interest for all the medical community Also describes the new, emerging therapeutical strategies for heart failure, based on modulation of thyroid hormone Includes supplementary material: sn.pub/extras