Tobacco-Specific N-Nitrosamines Recent Advances

1. Introduction 2. Formation and Analysis of Tobacco-Specific N-Nitrosamines 3. Synthesis of Tobacco-Specific N-Nitrosamines and Their Metabolites and Results of Related Bioassays 4. Endogenous Formation of Nitrosamines and Oxidative DNA-Damaging Agents in Tobacco Users 5. Recent Studies on Mechanisms of Bioactivation and Detoxification of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK), A Tobacco-Specific Lung Carcinogen 6. Epidemiology of Cancer by Tobacco Products and the Significance of TSNA 7. The Biological Significance of Tobacco-Specific N-Nitrosamines: Smoking and Adenocarcinoma of the Lung 8. Comparative Carcinogenicity, Metabolism, Mutagenicity, and DNA Binding of 7H-Dibenzo[c,g]carhazole and Dibenz[a,j]acridine 9. Concluding Remarks

This book presents critical assessments of subjects that are part of the advancing frontiers of toxicology and related basic scientific disciplines or issues that form the core of some of the most complex and intractable problems with which the toxicologist has to grapple.