PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems is an international yearly forum to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their ex-perience in the development of Agents and Multi-Agent Systems. This volume presents the papers that have been accepted for the 2010 edition in the Special Sessions and Workshops. PAAMS'10 Special Sessions and Workshops are a very useful tool in order to complement the regular program with new or emerging topics of particular interest to the participating community. Special Sessions and Workshops that emphasize on multi-disciplinary and transversal aspects, as well as cutting-edge topics were especially encouraged and welcomed.