TRP Channels in Health & Disease de Arpad Szallasi

TRP Channels in Health & Disease

Arpad Szallasi

Changes in temperature, either hot or cold, is sensed through direct activation of members of the temperature-sensitive transient release potential (TRP) ion channel superfamily, the so-called "thermoTRPs". Of the 28 TRP channels discovered today, seven sense hot or warm temperatures whereas two are activated by cold. Together, these channels cover a wide temperature range with extremes that fall between 10 C and 53 C. This new and unique book reviews research on TRP channels and their relation to health and disease.

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Cuprins

Foreword; TRP Channels in Health & Disease: An Overview; TRP Channelopathies; TRP Polymorphism; Complex Regulation of TRP Channels by PIP2; TRP Channel Trafficking; Disease-Related Changes in TRP Channel Expression: Clinical Studies; Targeting Supraspinal TRP Channels for Pain Relief; Role of Transient Receptor Potential Channels in Thermosensation & Thermoregulation; TRP Channels & Osmoregulation; TRP Channels & Blood Pressure Regulation; TRP Channels in Feeding & Body Weight; TRP Channels & Cancer; Transient Receptor Potential Channels in Kidney; TRP Channels in the Prostate & Urinary Bladder & Prostate: Implications for Therapy; TRP Channels in the Gastrointestinal Tract; TRP Channels & Airway Diseases; TRP Channels & Migraine; TRP Channels in Cutaneous Biology in Health & Disease; TRP Channels in Neurodegenerative Disease & Stroke; TRP Channels in Brain: Psychiatric Disorders; Role of TRP Channels in Drug Dependence; TRP Channels & Sepsis; Targeting TRP Channels: An Overview of Current Drug Discovery efforts & future directions; TRPV1 Agonists in Clinical Trials for Pain; TRPV1 antagonists in Clinical Trials; Concluding Remarks & Future Directions; Index.