It is the demand of 21st century and competitive global environment that Nepalese women are stepping outside their home for work. But, inside every women, the culture and their social values remains strong and they know balancing the 'progress and development' with their 'social values and the family'. Conflict and /or balancing between family and work responsibilities is concern to both male and female and also to both employees and employers. The balanced and hence dedicated and satisfied employee becomes highly productive and an important asset to an organization whereas, in other case the employee is the burden of the organization and becomes problem to the family. Thus, in organizations and on the home front, the challenge of balancing work and family responsibilities is rising to the top priority of many employers' and employees' consciousness. Knowledge regarding the factors that influence the balance of work and family would be beneficial to both employers and employees and the society as well. This study identifies and discusses the factors in work domain and family domain with respect to Nepalese women working in four sectors: civil service, financial sector, NGOs / INGOs