A Handbook of Bioanalysis and Drug Metabolism
Editat de Gary Evansen Limba Engleză Paperback – 25 sep 2019
This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
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Specificații
ISBN-13: 9780367394424
ISBN-10: 0367394421
Pagini: 408
Dimensiuni: 178 x 254 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
ISBN-10: 0367394421
Pagini: 408
Dimensiuni: 178 x 254 x 25 mm
Greutate: 0.45 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Public țintă
Academic and Professional Practice & DevelopmentCuprins
The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II Enzymes. In vitro Techniques for Investigating Metabolism. Drug–Drug Interactions: an in vitro Approach. Clinical Impact of Drug Interactions. Preclinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modeling in Preclinical Drug Discovery. Toxicokinetics. Protein Binding in Plasma: A Case History of a Highly Protein Bound Drug. Metabolite Identification by Spectroscopy. Whole Body Autoradiography. Radiolabeled Studies in Man. Molecular Biology.
Descriere
Taking a unique industrial perspective that reinforces theory and develops valuable analytical and interpretation skills, this book examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. Professionals with extensive experience in drug discovery and development, as well as specialized knowledge of the individual topics, contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics, and drug-drug interactions.