In this issue of Nursing Clinics of North America, guest editors Drs. Jacquelyn McMillian-Bohler and Stephanie Devane-Johnson bring their considerable expertise to the topic of Addressing Contemporary Issues in Women’s Health. Today’s women's health issues encompass a diverse range of challenges, and in this issue, top experts provide updates on many of the most pressing concerns in women’s health, including reproductive and mental health, wellness, obesity, and substance use disorder.