In this issue of Nursing Clinics of North America, guest editor Dr. Penni I. Watts, Assistant Dean for Clinical Simulation and Training at the University of Alabama School of Nursing, brings her considerable expertise to the topic of Healthcare Simulation in Nursing Practice. Simulation is typically utilized in nursing education, but there are many important uses, and positive outcomes, for simulation in the clinical setting. Topics covered include simulation for improving communication skills, professional integrity and ethical considerations, designing evidence-based scenarios for simulation experiences, plus many more. Top experts explore these topics with an eye on relevance to practicing bedside nurses.