This issue of Nursing Clinics, Guest Edited by Mimi Mahon, features subject topics such as: Understanding Children's Involvment in Medical Decision Making; Symptom Management at End of Life; Assessing respiratory distress when the patient can't self-report; Barriers to Palliative Care, Legislative Issues; End Stage Liver Disease: Symptoms & Practice Implications; Dying children: Creating opportunities out of a "Last Chance”; Decision making in palliative care; Discussing a family member's serious illness: children's and families' perspectives; Living with cognitive impairments in Long Term Care: Palliative Care & End of Life implications; Withdrawal of Life-Sustaining Therapy; The patient and family perspectives: Living with cancer; Palliative care concepts in the sickle cell population.