This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on the symptoms, diagnosis and treatment of Pompe disease; insulin resistance and its relation to intra-uterine growth retardation; evidence-based medicine research; the therapeutic values of Vitamin E supplements; megalin-mediated endocytosis in renal proximal tubule cells; and biofilm development kinetics.