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Affinity and Efficacy: The Components of Drug-Receptor Interactions de Frederick J. Ehlert

Affinity and Efficacy: The Components of Drug-Receptor Interactions

Autor Frederick J. Ehlert
en Limba Engleză Hardback – 9 dec 2014
The interaction of a drug with a receptor encodes a vector of information having components of affinity and efficacy. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction.
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Specificații

ISBN-13: 9789814322560
ISBN-10: 9814322563
Pagini: 752
Dimensiuni: 160 x 236 x 20 mm
Greutate: 0.66 kg
Editura: WORLD SCIENTIFIC

Cuprins

Ligand-Gated Ion Channels: Structure and Function of GABAA and Nicotinic Acetylcholine Receptors; Estimation of the Affinity and Efficacy of Orthosteric Ligands at Ligand-Gated Ion Channels; Allosteric Modulation of Ligand-Gated Ion Channels; G Protein-Coupled Receptors: G Protein-Coupled Receptors, G Proteins and Their Signaling Pathways; Affinity and Efficacy of the Agonist-Receptor-G Protein Interaction; Estimating Affinity and Efficacy by Reverse-Engineering the Response to Orthosteric Ligands; Analysis of Competitive Antagonism of the Response to Agonists; Allosteric Modulation of G Protein-Coupled Receptors; Ligand-Directed Signaling; Radioligand Binding: Analysis of Radioligand Binding Data.