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Aminoglycoside Antibiotics: Handbook of Experimental Pharmacology, cartea 62

Editat de Hamao Umezawa Contribuţii de Irving R. Hooper, Y. Ito, T. Koeda, S. Kondo, S. Mitsuhashi, T. Okuda, N. Tanaka, T. Tsuchiya, K. Umemura, S. Umezawa, M. Yokota
en Limba Engleză Paperback – 18 noi 2011

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Specificații

ISBN-13: 9783642685811
ISBN-10: 3642685811
Pagini: 392
Ilustrații: XVI, 372 p.
Dimensiuni: 170 x 244 x 21 mm
Greutate: 0.62 kg
Ediția:Softcover reprint of the original 1st ed. 1982
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

1 The Naturally Occurring Aminoglycoside Antibiotics.- A. Introduction.- B. Aminoglycoses and Noncyclitol Aminoglycosides.- C. Aminocyclitol Aminoglycosides Containing Streptamine, 2-Deoxystreptamine, or Their Derivatives.- D. Aminoglycosides with Cyclitol Aglycones Other than Streptamine or 2-Deoxystreptamine.- References.- 2 Total Synthesis and Chemical Modification of the Aminoglycoside Antibiotics.- A. Introduction.- B. Several Reactions and Methods Generally Useful for the Synthesis of Aminoglycoside Antibiotics.- C. Total Synthesis and Modification of Aminoglycoside Antibiotics.- References.- 3 Biosynthesis and Mutasynthesis of Aminoglycoside Antibiotics.- A. Introduction.- B. Biosynthesis of Major Aminoglycosides.- C. Mutational Biosynthesis (Mutasynthesis).- D. Conclusion.- References.- 4 Antibacterial Activity of Aminoglycoside Antibiotics.- A. Introduction.- B. Drug Resistance Plasmids.- C. Resistance Patterns of Bacteria.- D. Bacterial Strains Resistant to Aminoglycoside Antibiotics.- E. Conclusion.- References.- 5 Mechanism of Action of Aminoglycoside Antibiotics.- A. The Effects on Bacterial Cells and Their Components.- B. Effects on Mammalian or Eukaryotic Cells and Their Components.- C. Peptide Antibiotics Showing Similar Mechanisms of Inhibition of Ribosomal Functions.- D. Discussion.- E. Summary.- References.- 6 Mechanisms of Resistance to Aminoglycoside Antibiotics.- A. Introduction.- B. Biochemical Mechanisms of Resistance.- C. Derivatives Active Against Resistant Strains.- D. Conclusion.- References.- 7 Toxicology and Pharmacology of Aminoglycoside Antibiotics.- A. Introduction.- B. Nephrotoxicity of Aminoglycosides.- C. Ototoxicity of Aminoglycosides.- D. Acute Lethal Toxicity of Aminoglycosides.- E. Correlation Between Chemical Structure and LD50 Values of Aminoglycosides.- F. General Pharmacology of Aminoglycosides.- G. Pharmacokinetics.- References.