Targeting Trafficking in Drug Development de Alfredo Ulloa-Aguirre

Targeting Trafficking in Drug Development: Handbook of Experimental Pharmacology, cartea 245

Alfredo Ulloa-Aguirre

Ya-Xiong Tao

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

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Paperback (1)	1607^.74 lei 22-36 zile
Springer International Publishing – 15 feb 2019	1607^.74 lei 22-36 zile
Hardback (1)	2117^.38 lei 22-36 zile
Springer International Publishing – 27 apr 2018	2117^.38 lei 22-36 zile

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Express

Paperback (1)

1607^.74 lei 22-36 zile

Springer International Publishing – 15 feb 2019

1607^.74 lei 22-36 zile

Hardback (1)

2117^.38 lei 22-36 zile

Springer International Publishing – 27 apr 2018

2117^.38 lei 22-36 zile

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Specificații

ISBN-13: 9783319741635
ISBN-10: 3319741632
Pagini: 392
Ilustrații: VIII, 425 p. 57 illus., 55 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.76 kg
Ediția:1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

1. Intracellular trafficking of gonadotropin receptors in health and disease.- 2. Investigating internalization and intracellular trafficking of GPCRs.- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors.- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases.- 5. Pharmacoperones for misfolded gonadotropin receptors.- 6. Pharmacological chaperones: Beyond conformational disorders.- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer.- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches.- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking.- 10. SLC6 transporter folding diseases and pharmacochaperoning.- 11. The molecular physiopathogenesis of islet amyloidosis.- 12. Folding defects leading to primary hyperoxaluria.- 13. Potentialpharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.