Animal Models for Development of Cancer Immunotherapy
Editat de Seng–Lai Tanen Limba Engleză Hardback – 14 dec 2022
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Specificații
ISBN-13: 9781119535287
ISBN-10: 111953528X
Pagini: 450
Dimensiuni: 10 x 10 x 10 mm
Greutate: 0.59 kg
Editura: Wiley
Locul publicării:Hoboken, United States
ISBN-10: 111953528X
Pagini: 450
Dimensiuni: 10 x 10 x 10 mm
Greutate: 0.59 kg
Editura: Wiley
Locul publicării:Hoboken, United States
Descriere
Animal Models for Development of Cancer Immunotherapy provides a detailed overview of different preclinical model systems for development of novel cancer immunotherapies while highlighting how key aspects of individual models translate into clinical findings.
- Emphasizes the importance of modeling tumor metastasis in preclinical models for efficient translation of findings into the clinic
- Explores recently discovered mechanisms of resistance and their preclinical modeling
- Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models
- Reviews development of bone marrow-liver-thymus (BLT) immune humanized mice and emerging alternative models such as genetically engineered mouse models (GEMM)
- Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs