Anion Channels and Transporters: Handbook of Experimental Pharmacology, cartea 283
Editat de Christoph Fahlkeen Limba Engleză Hardback – 5 ian 2024
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Specificații
ISBN-13: 9783031513459
ISBN-10: 3031513452
Pagini: 362
Ilustrații: X, 362 p. 100 illus., 30 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.79 kg
Ediția:1st ed. 2024
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Cham, Switzerland
ISBN-10: 3031513452
Pagini: 362
Ilustrații: X, 362 p. 100 illus., 30 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.79 kg
Ediția:1st ed. 2024
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Cham, Switzerland
Cuprins
Preface.- Muscle chloride channels.- Adrenal anion channels - new roles in zona glomerulosa physiology and in the pathophysiology of primary aldosteronism.- ClC-K Kidney Chloride Channels : from structure to pathology.- Biophysical and pharmacological insights to CLC chloride channels and Transporters.- Function and regulation of the calcium-activated chloride channel anoctamin 1.- Structure and function of calcium-activated chloride channels and scramblases in TMEM16 family.- Structural basis for anion-selective Cys-loop receptor signal transduction and modulation.- Physiological functions of the volume regulated anion channel VRAC/LRRC8 and the proton-activated chloride channel PAC/TMEM206.- CFTR modulators: from mechanism to targeted therapeutics.- Structure, physiology, and pharmacology of chloride-dependent cation cotransporters.- SLC26 Anion Transporters.- Pharmacology of Na-dependent transporters of inorganic phosphate.- Simulation of fluoride anions in CLC proteins: from potent inhibition to selective transport.
Caracteristici
Describes mechanisms that ensure selective anion transport across biological membrane Illustrates the variability of cellular processes that are regulated by anion channels and transporters Explains how anion channel/transporter dysfunction can cause severe human diseases