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Breast Cancer Metastasis and Drug Resistance: Progress and Prospects de Aamir Ahmad

Breast Cancer Metastasis and Drug Resistance: Progress and Prospects

Editat de Aamir Ahmad
en Limba Engleză Hardback – 8 noi 2012
​This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and c) understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity/metastasis/drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed.  ​
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Specificații

ISBN-13: 9781461456469
ISBN-10: 1461456460
Pagini: 428
Ilustrații: XII, 416 p.
Dimensiuni: 155 x 235 x 28 mm
Greutate: 0.77 kg
Ediția:2013
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Preface.- Breast Cancer Statistics.- Epidemiology of Breast Cancer in Women.- The Complexities of Racial Disparity in Breast Cancer.- Major signaling pathways involved in Breast Cancer.- Breast Cancer Heterogeneity in Primary and Metastatic Disease.- Understanding Triple-negative Breast Cancer.- The biology of the deadly love connection between obesity, diabetes and breast cancer.- Progression of Early Breast Cancer to an Invasive Phenotype.- Pre-clinical modeling of breast cancer – which model to choose?.- Modeling breast cancer progression in 4-D.- Bone Metastasis of Breast Cancer.- Cellular and Molecular Mechanisms Involved in Breaching of The Blood-Brian Barrier By Circulating Breast Cancer Cells.- Resistance to Anthracyclines and Taxanes in Breast cancer.- Understanding of Tamoxifen Resistance of Breast Cancer based on Integrative Bioinformatics Approaches.- Current understanding of drug resistance mechanisms and therapeutic targets in HER2 overexpressing breast cancers.- Platinum and ruthenium complexes for the therapy of breast cancer diseases.-Development of Notch Pathway Inhibitors for Cancer Therapy.- Systems Biology Approaches in Breast Cancer Studies.- Epigenetic Factors in Breast Cancer Progression.- Breast Cancer Stem Cells and miRNAs.- Breast Cancer Stem Cells: responsible for therapeutic resistance and relapse?.- MicroRNAs in Breast Cancer Research: Progress and Promise.- Index.

Textul de pe ultima copertă

This comprehensive book on breast cancer brings together some of the leading experts in an attempt to better understand breast cancer disease, the factors that make it lethal and current research progress, integrating both basic research with clinical implications. This volume covers the following core issues: i) heterogeneity in breast cancer – statistics, epidemiology, breast cancer subtypes, racial disparity and the associated challenges, ii) available and upcoming model systems in breast cancer research, iii) breast cancer metastasis to bones and brain, iv) drug resistance mechanisms in breast cancer against targeted therapies and v) recent developments in breast cancer research – state of current research directions / technologies / approaches. With its comprehensive coverage of topics related to breast cancer, this volume is expected to have a very wide appeal. It serves as an excellent source of reference for students/beginning researchers just setting foot in the field and interested in getting to know all the aspects of this disease. The book should also appeal to advanced and senior researchers by bringing everyone up-to-date with the most current knowledge on various breast cancer topics of utmost relevance

Caracteristici

Explores breast cancer, the factors that make it lethal and current research progress, including stem cells, microRNAs, epigenetics, genomics and some novel signaling pathways? Excellent source for of reference for researchers? Features up-to-date research Includes supplementary material: sn.pub/extras

Notă biografică

Aamir Ahmad, PhD, is Assistant Professor of Oncologic Sciences at University of South Alabama’s Mitchell Cancer Institute, Mobile, AL, USA. He received his academic degrees from AMU, Aligarh, India and completed post-doctoral training at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. His research interests include understanding the mechanisms of cancer drug resistance and metastasis in different cancers, with emphasis on the role of microRNAs, non-coding RNAs, epigenetics, exosomes, cancer stem cells and a personalized approach. He has authored 160 scientific research / review articles, edited/co-edited 8 books and serves as Expert Reviewer for scientific proposals submitted to 8 different funding agencies in Europe, Asia and Africa. He is the Founding Editor-in-Chief of the journal “Non-coding RNA Research”, Section Editor for the journal “Scientific Reports”, and is Section Editor for the journal “PLoS ONE”. He is also the Editor-in-Chief of the Elsevier series ‘Cancer Metastasis’.